Page 208 - Veterinary Immunology, 10th Edition

VetBooks.ir

FIG. 7.9 The pathogenesis of staphylococcal toxic shock
syndrome. The toxic shock syndrome toxin is a potent superantigen
that acts as a powerful stimulant of IL-1 and TNF-α production.

SIRS-Associated Laminitis

Acute laminitis is a common debilitating disease in horses and
ponies. While traditionally considered a single entity, laminitis is
now recognized to result from several different mechanisms: these
include endocrinopathic disease caused by prolonged

hyperinsulinemia, support-limb laminitis caused by prolonged
weight-bearing on one hoof, and inflammation-related laminitis.
Experimentally, inflammation sufficient to trigger laminitis can be

208