Page 225 - Veterinary Immunology, 10th Edition

VetBooks.ir Cytokine Receptors

Cytokines act through cell surface receptors. These receptors consist
of at least two functional units, one for ligand binding and one for

signal transduction (Fig. 8.3). These units may or may not be on the
same protein. Cytokine receptors can also be classified into classes
based on their structure.

FIG. 8.3 The structure of a cytokine receptor, in this case, the IL-2
receptor complex. The complete trimer serves as a high-affinity
receptor, whereas the β-γ dimer serves as a low-affinity receptor.
Note that different receptor components each serve different
functions.

One class of receptor includes the channel-linked receptors,

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