Page 475 - Veterinary Immunology, 10th Edition

Horses, 170
VetBooks.ir Cattle, 170

Sheep, 171

Pigs, 172

Dogs and Cats, 172

Primates, 172

Other Mammals, 172

LEARNING OBJECTIVES

After reading this chapter, you should be able to:
• Explain the relationship between BCRs and circulating antibodies.

• Recognize that mammals make five classes of immunoglobulins:
immunoglobulin G (IgG), IgM, IgA, IgE, and IgD.
• Describe how IgG is the predominant immunoglobulin in serum and is mainly

responsible for systemic defense.
• Explain why IgM is mainly produced during a primary immune response.
• Briefly describe the role of IgA on body surfaces. What is its function?

• Explain that IgE functions in immunity to parasitic worms and as a cause of
allergies.
• Recognize that IgD is found on the surface of immature lymphocytes and its

function is unclear.
• Describe the basic structure of each of the five immunoglobulin classes.
• Explain the significance of immunoglobulin subclasses (or isotypes).

• Explain how immunoglobulin heavy chain genes can undergo class switching.
• Explain how immunoglobulins can exist in both cell-bound and soluble forms.

• Understand the unique structure of bovine and camel immunoglobulins.

The properties of the B cell antigen receptors (BCRs) were discussed

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