Page 578 - Veterinary Immunology, 10th Edition

Horses, 204
VetBooks.ir Cattle, 204

Sheep, 205

Pigs, 205

Dogs, 205

Cats, 206

NKT Cells, 206

Species Differences, 206

LEARNING OBJECTIVES

After you read this chapter, you should be able to:

• Understand that T cell subpopulations have innate counterparts.
• Describe how innate lymphoid cells (ILCs) use antigen receptors encoded by

germline genes.
• Explain that ILCs can be divided into two major groups based on their functions:
the helper innate cells and cytotoxic innate cells.

• List and describe the functions of the three types of helper-like innate cells.
• Explain the major properties of NK cells.

• Explain how NK cells can kill virus-infected target cells, tumor cells, stressed
cells, and some bacteria without prior activation.
• Understand why NK cells act as a first line of defense against pathogens such as
viruses.

• Explain how NK cells employ a “missing-self” recognition strategy.
• Describe how NK cells can also recognize and attack target cells that express

stress-associated molecules.
• Recognize that the destruction of some tumors probably involves killing by NK
cells.
• Define the importance of CD1 molecules in the processing of lipid antigens.

• Define ILC, NK cell, NKT cell, KIR, Ly49, and NKG2.

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