Page 578 - Veterinary Immunology, 10th Edition
P. 578
Horses, 204
VetBooks.ir Cattle, 204
Sheep, 205
Pigs, 205
Dogs, 205
Cats, 206
NKT Cells, 206
Species Differences, 206
LEARNING OBJECTIVES
After you read this chapter, you should be able to:
• Understand that T cell subpopulations have innate counterparts.
• Describe how innate lymphoid cells (ILCs) use antigen receptors encoded by
germline genes.
• Explain that ILCs can be divided into two major groups based on their functions:
the helper innate cells and cytotoxic innate cells.
• List and describe the functions of the three types of helper-like innate cells.
• Explain the major properties of NK cells.
• Explain how NK cells can kill virus-infected target cells, tumor cells, stressed
cells, and some bacteria without prior activation.
• Understand why NK cells act as a first line of defense against pathogens such as
viruses.
• Explain how NK cells employ a “missing-self” recognition strategy.
• Describe how NK cells can also recognize and attack target cells that express
stress-associated molecules.
• Recognize that the destruction of some tumors probably involves killing by NK
cells.
• Define the importance of CD1 molecules in the processing of lipid antigens.
• Define ILC, NK cell, NKT cell, KIR, Ly49, and NKG2.
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