Page 578 - Veterinary Immunology, 10th Edition
P. 578

Horses, 204
  VetBooks.ir            Cattle, 204




                         Sheep, 205


                         Pigs, 205

                         Dogs, 205


                         Cats, 206


                 NKT Cells, 206

                         Species Differences, 206








               LEARNING OBJECTIVES



                 After you read this chapter, you should be able to:

                 • Understand that T cell subpopulations have innate counterparts.
                 • Describe how innate lymphoid cells (ILCs) use antigen receptors encoded by

                   germline genes.
                 • Explain that ILCs can be divided into two major groups based on their functions:
                   the helper innate cells and cytotoxic innate cells.

                 • List and describe the functions of the three types of helper-like innate cells.
                 • Explain the major properties of NK cells.

                 • Explain how NK cells can kill virus-infected target cells, tumor cells, stressed
                   cells, and some bacteria without prior activation.
                 • Understand why NK cells act as a first line of defense against pathogens such as
                   viruses.

                 • Explain how NK cells employ a “missing-self” recognition strategy.
                 • Describe how NK cells can also recognize and attack target cells that express

                   stress-associated molecules.
                 • Recognize that the destruction of some tumors probably involves killing by NK
                   cells.
                 • Define the importance of CD1 molecules in the processing of lipid antigens.

                 • Define ILC, NK cell, NKT cell, KIR, Ly49, and NKG2.





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