Page 628 - Veterinary Immunology, 10th Edition
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FIG. 20.11 The mechanisms by which Treg cells can suppress
other immune responses.
A second set of pathways, inhibition by suppressive cytokines, is
used predominantly by pTreg cells. These cytokines include IL-10,
TGF-β, and IL-35 as well as competitors for cytokine receptors. IL-
10 is the most important of these (Fig. 20.12). As a result of all these
mechanisms, Treg cells suppress the response of helper T cells to
antigens and prevent inappropriate T cell activation in the absence
of an antigen. Treg cells can also suppress CD4 and CD8 T cell
responses by pathways independent of IL-10 and TGF-β. For
example, they appear to shorten the interaction time between T
cells and APCs and thus prevent activation.
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