Page 682 - Veterinary Immunology, 10th Edition

Immunoproliferative enteropathy of Basenji dogs is an inherited
VetBooks.ir autosomal disease that presents as gastric mucosal hypertrophy

with lymphoid cell infiltration and ulceration. The whole small
intestine may show villous blunting, crypt elongation, and

infiltration of the mucosa with lymphocytes, plasma cells, and some
neutrophils. Dogs show a polyclonal increase in serum IgA. The
disease may be controlled by high doses of corticosteroids.
Protein-losing enteropathy of soft-coated Wheaten Terriers is also

an inherited disease. Histological examination shows an
inflammatory bowel disease. The cellular infiltrates are mainly
lymphocytes and plasma cells, but neutrophils and eosinophils are
often present. This disease may result from food hypersensitivity,

possibly to wheat gluten.
Gluten sensitive enteropathy of Irish Setters is an autosomal
recessive small intestinal disease also caused by exposure to wheat
gluten. As with the diseases described previously, affected small

intestine is infiltrated with lymphocytes and other inflammatory
+
cells. The mucosa shows increased numbers of CD4 cells and
+
decreased CD8 T cell numbers. Affected dogs may also have
elevated serum IgA levels.

Lymphocytic-plasmacytic enteritis has also been described in
cats, horses, and a cow. Equine inflammatory bowel disease also
encompasses several different diseases. However, rectal biopsies of
affected horses suggest that increase numbers of IL-17 cells may be

involved in the active disease. There is also a reduction in
antiinflammatory Treg activity.

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