Page 364 - The Toxicology of Fishes

344 The Toxicology of Fishes

Zebrafish Ceruloplasmin f (16 hpf) Heartbeat, prox1/hhex, d,g Liver bud (24–28 hpf), prox1/hhex, d,g FoxA2, Selenoprotein (28 hpf), prox1/hhex, d,g FoxA2, prox1/hhex, d,g FoxA3, e,h prox1/hhex, d,g FoxA3, e,h prox1/hhex, d,g FoxA3, e,h HNF1α, e prox1/hhex, d,g HNF4, e HNF6, c Sox17 e — — — — — —
HNF6 c (6 hpf) HNF1β i — FoxA2, FoxA3 e,h FoxA3 e,h FoxA3 e,h HNF4 e HNF4 e HNF4 e (53 hpf)

Medaka — — — — — — — — — — gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b gata6, b foxA3 b

Hallmarks of Hepatobiliary Development in ST II Medaka Compared to Related Aspects of Zebrafish Development

Description Early neurula: rudimentary brain, beak-like mass Late neurula: brain and nerve cord, Kupffer’s vesicles Otic vesicles appear; three parts of brain discernable; optic cups appear Optic cups form; lenses apparent; neural fold distinct; otic vesicles distinct (no Heart anlage appears; hatching glands appear as cell mass 33–64/min pulse; gut tube ventral; vitello-caudal vein appears on yolk sphere; Small cell mass bulging from foregut of ventr

Blastula/gastrula blood island apparent at 6–11 somites. beneath the third somite to feed liver from left dorsal aorta β-naphthoflavone and TCDD

Blastula Blastula Gastrula otoliths)

Feature — — — — Neural/brain a Optic buds a Otic vesicle a Optic cups a Heart a Heartbeat a Liver anlage Gallbladder Gut tube CYP3A activity Hepatic tubules Pancreas CYP1A activity

Hpf 6 8 10 21 25 — — 34 38 44 50 58 — 62 62 64 68

Som — — — — — — 4 6 9 16 18 24 — 28 28 30 —

TABLE 7.4 Hr Dpf — — — — — — — — 1 1 2 8 10 14 20 2 2 10 — — — 16 —