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The Ādam Paradox Hypothesis 160
CNTNAP2 — FOXP2’s Partner (~200 ka)
Target of FOXP2, linked to autism and speech disorders (Vernes et al., 2008).
Evolutionary gap: tuned circuits existed, culture mute.
APH view: FOXP2-CNTNAP2 network activated only at Adamic
threshold.
SHH Regulatory Enhancers — Hemispheric Specialization (~200 ka)
Sonic Hedgehog (SHH) pathways control brain asymmetry. Human-specific
enhancer mutations alter hemispheric development (Prabhakar et al., 2008).
Evolutionary gap: left/right asymmetry ready, no symbolic language yet.
APH view: switch prepared for language lateralization, activated later.
HAR2 (HACNS1) — Motor Planning (~300 ka)
HAR2 is a human-accelerated enhancer linked to thumb and wrist function
(Prabhakar et al., 2008).
Evolutionary gap: refined hand control long before art.
APH view: prepared gesture-tool link, fulfilled in symbolic art and writing.
ZEB2 — Skull & Neural Crest (~250 ka)
Regulatory edits in ZEB2 affect neural crest migration, reshaping skull base
(Bae et al., 2014).
Evolutionary gap: reshaped vocal tract long before symbolic speech.
APH view: vessel shaped, awaiting infused voice.
ERV Insertions — Viral Tools as Editors
Endogenous retroviruses contributed regulatory elements in placenta and brain
(Feschotte, 2008).
Evolutionary gap: retroviral insertions positioned long before symbolic
culture.
APH view: divine engineering used viral tools to install new circuits.