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The Ādam Paradox Hypothesis 240
2. Stem-cell derived brain organoids
“Mini-brains” grown from human stem cells that replicate some brain
development processes.
Scientists can introduce FOXP2 or HAR1 variants into organoids and
measure differences in neuronal growth, connectivity, and rhythm
compared to controls.
They don’t “think” like us but provide a living testbed for biological
plausibility.
3. EEG/fMRI validation
EEG (electroencephalography) measures brainwave oscillations. fMRI
(functional MRI) maps active regions during tasks.
Comparing brain activity in people with different gene variants helps
connect genetic changes to real cognitive effects.
Example: individuals with FOXP2 disruptions show abnormal brain
activity in speech areas.
Expected Outcome
Direct evidence on whether small DNA changes (in FOXP2, HAR1, etc.)
can significantly alter brain networks linked to language and symbolism.
If organoid and simulation studies show big cognitive differences from
small regulatory tweaks, it supports APH’s ignition model.
If no significant effects are found, the evidence leans toward gradual
accumulation of cognitive capacity.
Likely Scenario:
Early evidence already links FOXP2 and HAR1 to neural development and
language. With organoid and simulation methods advancing rapidly,
neuroscience will probably show that relatively small, targeted regulatory
changes can trigger disproportionately large effects in brain function —
consistent with APH’s ignition hypothesis.