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%u03b3-PGA increases bone Ca content%u03b3-PGA promotes the growth of osteoblast cells%u03b3-PGA increases femur bone densityEffectiveness of %u03b3-PGA on Bone FormationGlobal PatentsBone Density of Frmur (g/cm3)%u03b3-PGA1.81.61.41.00.81.20.60.20.40H20 5 10 40 (mg/kg)Femur Ca content (mg/cm3)%u03b3-PGA350200250200150100500H20 5 10 40 (mg/kg)%u03b3-PGA concentration(%)Growth rate of osteoblast cell (%)0 505x10-21.25x10-26.2x10-33.9x10-4100 150 200%u03b3-PGA concentration(%)Activity of alkaline phosphataseOD410 nm0 0.3 0.6 0.9 1.2 1.5 1.80.0250.0510.01250Safty AssessmentsTest Items ResultsReverse Gene Mutation Testing (AMES Test)Acute Oral Toxicity TestingNOAEL (No-ObservedAdverse-Effect Level): 1,000 mg/kg/dayNegativeLD50 > 2,000 mg/kg28-Day Subacute Oral Toxicity TestingUS Europe Vietnam China Taiwan Japan
