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© 2019 ASPEN | American Society for Parenteral and Enteral Nutrition. All Rights Reserved. Selection of ILE
• New products now commercially available
o Mixed oils provide more options for providing lipids
• No clear guidelines on when to use alternative ILE’s
• Additional research needed
o Most trials are short-term
o Potential positive outcomes in critically ill patients and home PN patients
• Need to monitor for adequacy of EFA’s
o Alternative ILE’s contain lower concentration of EFA’s
o Need to assess adequacy of EFA’s with alternative ILE’s
- 4-oil ILE studies based on a minimum of 1g fat/kg/day
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Clinical Outcomes: Alternative ILE in Critical Illness
© 2019 ASPEN | American Society for Parenteral and Enteral Nutrition. All Rights Reserved. • Olive Oil-Soybean Oil ILE:
o Shorter time to liberation from mechanical ventilation1
o Shorter time to ICU discharge alive 1
o May be useful as a strategy to reduce n-6 intake from soybean based lipids
• 4-Oil ILE:
o Shorter time on mechanical ventilation1
o Reduction in nosocomial infections2
o Decreased risk of elevated triglyceride levels3
o Lower inflammatory markers (TNF-α and IL-6)3
o Lower liver functions tests3
1. Edmunds CE. Crit Care Med 2014; 42:1168–117. 76
2. Grau-Carmona T. Crit Care Med 2015;43:31-39.
3. Honeywell S. Nutr Clin Pract. 2019;34(1):112-122.
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