Page 63 - Medicinal Chemistry Self Assessment

A
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C

O B O D
E
O
OH
H 3 C CH 3
Cl Fluvoxamine

Fenofibric Acid
52 1. Conduct a structural evaluation of
Medicinal Chemistry Self Assessment

2. for your answer.
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2. Fluvoxamine is marketed as a single isomer. Is the product sold as a single enantiomer, diastereomer,

or geometric isomer? Provide a brief rationale for your answer.

A
F C B F C
3
3
1' C O D
2' CH 3 1' 2' O CH
N NH 2 1 3
2 1 O H 2 N O N 2
E
A B
Fluvoxamine

3. Fluvoxamine is formulated as a maleate salt. What type of salt is a maleate salt, and what type of
3. Fluvoxamine is formulated as a maleate saltes of the drug?
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properties does it confer to the overall properties of the drug?

F C
3
O
CH 3
N NH 3 – O O
O O

OH
Fluvoxamine maleate

Fluvoxamine maleate

4. Fluvoxamine is well absorbed and has an oral bioavailability of ~50%. Using the information found in
4. Fluvoxamine is well tic properties.

the structure evaluation grid, provide a rationale for these pharmacokinetic properties.

5. A number of occurred.