Page 54 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

E) Effect of Alkalis on Monosaccharide:

Dilute alkalis catalyses mutarotation (isomerization):

• A process taking place mainly at the reducing end of the molecule and

rearrangement of the hydroxyl group at C-2 is termed “epimerization”.

• When D-glucose is treated with dilute alkalis for several hours, it

undergoes isomerization giving an equilibrium mixture of D-glucose, D-

mannose and D-fructose.

• This results in the formation of a common intermediate enediol.

• The process of shifting of hydrogen atom from one carbon to another to

produce enediols is known as tautomeization.

35