Page 185 - Basic _ Clinical Pharmacology ( PDFDrive )

CHAPTER 10 Adrenoceptor Antagonist Drugs 171

Pharmacokinetics,
Subclass, Drug Mechanism of Action Effects Clinical Applications Toxicities, Interactions
• Esmolol β 1 > β 2 Very brief cardiac Rapid control of BP and Parenteral only • half-life
β blockade arrhythmias, thyrotoxicosis, ~10 min • Toxicity: Bradycardia
and myocardial ischemia • hypotension
intraoperatively
TYROSINE HYDROXYLASE INHIBITOR
• Metyrosine Blocks tyrosine hydroxylase Lowers BP • may elicit Pheochromocytoma Toxicity: Extrapyramidal
• reduces synthesis of extrapyramidal effects (due symptoms • orthostatic
dopamine, norepinephrine, to low dopamine in CNS) hypotension • crystalluria
and epinephrine
1
Not available in the USA.

PREP AR A TIONS A V AIL ABLE *

GENERIC NAME AVAILABLE AS GENERIC NAME AVAILABLE AS
ALPHA BLOCKERS Carvedilol Coreg
Alfuzosin Uroxatral Esmolol Brevibloc
Doxazosin Generic, Cardura Labetalol Generic, Normodyne, Trandate
Phenoxybenzamine Dibenzyline Levobunolol Betagan Liquifilm, others
Phentolamine Generic Metipranolol OptiPranolol
Prazosin Generic, Minipress Metoprolol Generic, Lopressor, Toprol
Silodosin Rapaflo Nadolol Generic, Corgard
Tamsulosin Flomax Nebivolol Bystolic
Terazosin Generic, Hytrin Penbutolol Levatol
Tolazoline Priscoline Pindolol Generic, Visken
BETA BLOCKERS Propranolol Generic, Inderal
Acebutolol Generic, Sectral Sotalol Generic, Betapace
Atenolol Generic, Tenormin Timolol
Betaxolol Oral Generic, Blocadren
Oral Kerlone Ophthalmic Generic, Timoptic
Ophthalmic Generic, Betoptic TYROSINE HYDROXYLASE INHIBITOR
Bisoprolol Generic, Zebeta Metyrosine Demser
Carteolol
Oral Cartrol
Ophthalmic Generic, Ocupress
* In the USA.

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