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Autism and the Endocannabinoid System – Part 2

In the previous article, we discussed Curaleaf: 15:1 euphoric, and uplifted.
the following: Grow Healthy: 18:1 and 14:1 • Charlotte’s Web - Is a legendary
Knox: 40:1 medicinal strain for numerous debilitat-
• The basics about Autism Spectrum
Liberty Health Sciences: 26:1 and 20:1 ing disorders, particularly epilepsy, anxi-
Disorder (ASD)
MÜV: N/A ety, and autism. This sativa strain is a
• The epidemiology of ASD Surterra: 12.5:1 and 5:1 strong CBD, with just an average of .3%
• Screening and Diagnosis for ASD The Green Solution: 16:1 THC which means that patients won’t get
• The “traditional”, “new” and Trulieve: 20:1 and 16:1 a “high” with Charlotte’s Web but it will
“unconventional” causes and risk fac- A pending U.S. clinical trial, that was provide the patient with all the therapeu-
scheduled to start in October of 2018 and tic benefits that they need. However take
tors for autism spectrum disorder
finalized in September 2021 is studying note when medicating with Charlotte’s
• How the Endocannabinoid System
the efficacy and safety of cannabidivarin Web; while for many cases it’s proven as
(ECS) relates to ASD (CBDV) in 100 children with ASD. We an effective cure-all, some find no relief;
• Types of treatments for ASD BY JOSEPH ROSADO, MD, MBA are all looking forward to the publishing it is best recommended to experiment
• Medical cannabis friendly states for of these results. with this at low to moderate doses and
Now, let’s discuss the medicinal observe. When it does work, Charlotte’s
Autism Spectrum Disorder
were much improved or very much cannabis strains for the management of Web has done miracles for countless
In this article we will be addressing,
improved (on the CGIC scale) in 61% of patients with autism! cases, so it is definitely worth a try for
• Management of Autistic Patients
patients. The anxiety and communica- • Blue Dream - A sativa-dominant cases of autism.
with Medical Cannabis tion problems were much or very much hybrid and one that’s widely used among • Hindu Kush - This is a pure indica
• Clinical studies supporting the improved in 39% and 47% respectively. patients with autism, as well as PTSD. hailing from the mountain ranges from
management of patients with Autism Disruptive behaviors, were improved by Many users tout Blue Dream to be the which it’s named. Many patients of
29% from 4.74±1.82 as recorded at base- cannabis form of aspirin, which means autism find great relief from medicating
with medical cannabis
line on the HSQ-ASD to 3.36±1.56 fol- that it should basically be in everyone’s with Hindu Kush; i.e., its ability to
• Medicinal cannabis strains for the
lowing the treatment. medicine cabinet. LOL This is an excel- induce a sense of calmness and tranquil-
management of patients with Autism Parents reported less stress as reflected lent strain for daytime medication and ity is therapeutic for patients. Aside from
in the APSI scores, changing by 33! can effectively suppress pain, discomfort, autism, Hindu Kush is also known to be
The endocannabinoid system in the Therefore, based on these promising and all the symptoms of autism. Low effective in treating pain, anxiety, depres-
body is considered as the reason for results, the researchers have launched a doses of Blue Dream are recommended sion, stress, and of course insomnia.
many disorders and recent researchers’ large, double blind, placebo controlled for the treatment of autism; to get the Autistic patients can relax with the mel-
state that it might help in the treatment cross-over trial with 120 participants. right low dose many parents turn to low, deep, yet euphoria it delivers.
of autism. The chronic neuroinflamma- In another study done in Chile, South administering their children with tinc- Because it’s a pure indica, Hindu Kush is
tion can be eased with the help of the America (2) , the researchers expanded on tures of this excellent therapeutic strain. recommended for medication only at
antioxidants which are present in the preclinical studies’ suggestion of a dys- • Green Crack - Has become a house- night, helping autistic patients have a
cannabis plant. Cannabis helps with functional endocannabinoid system hold name in the medical cannabis com- restful and deep slumber while helping
mood and behavior of the patients in implicated in Autism Spectrum Disorder munity because of its far-reaching thera- them feel more refreshed the next day.
terms of emotions and aggressive out- (ASD). 20 children and one adult patient peutic benefits especially in the treat-
bursts. were selected. Mean age: 9 years, 10 ment of autism. Green Crack does won-
Cannabinoids are believed to remove months (range: 26 mo-22 yo), 15 males. ders for the mind, and despite being an (1) Aran A, Cassuto H, Lubotzky A.
the damaged brain cells and to improve 66,7% of patients had significant energetic strain can help relax the mus- Cannabidiol Based Medical Cannabis in
the efficiency of mitochondria. With the improvement according to CGI-I and cles in a way that few other strains can. Children with Autism- a Retrospective
Feasibility Study (P3.318). April 10, 2018; 90
help of CBD, children can be protected APSI. Most cases improved at least one of This strain is a well-loved medical choice (15 Supplement) APRIL 24, 2018
from the neurodegenerative diseases. the core symptoms of ASD, including because it does not lead to a mental crash
Cannabinoids help the brain to achieve social communication, language, or once the effects fade away, so it’s gentle (2) Kuester G, Vergara K, Ahumada A,
breakthroughs in learning, which also repetitive behaviors. enough for those with autism, allowing Gazmuri AM. Oral cannabis extracts as a
helps in gaining consciousness and bet- Additionally, sensory difficulties, food them to gently ease in and out of the promising treatment for the core symptoms of
autism spectrum disorder: Preliminary expe-
ter understanding. For the sleep issues, acceptance, feeding and sleep disorders, euphoria. Patients will also appreciate rience in Chilean patients. October 15, 2017.
this can be addressed by bringing the and/or seizures were improved in most that Green Crack helps put them in a Volume 381, Supplement, Pages 932–933.
endocannabinoid system into balance, cases. 71.5% of patients received bal- more focused mood, while feeling happy,
ensuring proper health. anced CBD:THC (1:1) extracts; 19.0%
In a retrospective study performed by high-CBD (20:1); and 9.5% high-THC
Dr. Aran (1) , in Israel, assessed the safety, (1:4) extracts. Oral cannabis extracts
tolerability and efficacy of cannabidiol were well tolerated. Two patients had
(CBD) based medical cannabis, as an more agitation and one had more irri-
adjuvant therapy, for refractory behav- tability, effects that were solved by chang-
ioral problems in children with ASD. ing the strain.
Sixty children with ASD (mean age was In this small series of ASD patients,
11.8± 3.5, range 5.0–17.5; 77% low func- oral cannabis extracts were dramatically
tioning; 83% boys) were treated with oral more effective than conventional medi-
CBD and tetrahydrocannabinol (THC) at cines. However, large randomized con-
a ratio of 20:1. The dose was up-titrated trolled trials are needed to establish effi-
to effect (maximal CBD dose − cacy and safety of medicinal cannabis in
10mg/kg/d). ASD.
Tolerability and efficacy were assessed Notice that the way the Chilean study
using a modified Liverpool Adverse addressed the three adverse reactions was
Events Profile, the Caregiver Global by changing the strains that the patients
Impression of Change (CGIC) scale, the were taking, therefore, it is paramount
Home Situations Questionnaire–Autism that the provider be aware of the different
Spectrum Disorder (HSQ-ASD) and the ratios and strains available at the local
Autism Parenting Stress Index (APSI). dispensaries.
Results revealed that following the In FL, this is what is available:
cannabis treatment, behavioral outbreaks

South Florida Hospital News southfloridahospitalnews.com December 2018 35