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4.5
                                                                      4.0
                     Respiratory and    Other
                     digestive diseases                               3.5

                                                                      3.0
                     Maternal
                     and                 8.6%
                     perinatal                 Infectious             2.5
                     conditions    10.3%        diseases
                                                23.4%               Annual deaths (millions)  2.0
                                  6.3%

                       Injuries   9.8%        Cardiovascular          1.5
                                                 diseases             1.0
                                      12.6%      29.0%
                                                                      0.5
                           Cancers
                                                                       0
                                                                         Respiratory  Diarrheal  AIDS  TB  Malaria Childhood
                                                                          infections diseases                     diseases
                                                                          (influenza,                             (measles,
                                                                       pneumonia, etc.)                           pertussis,
                                                                                                                 tetanus, etc.)
                     (a) Leading causes of death across the world  (b) Leading causes of death by infectious diseases
                     Figure 14.3 Infectious diseases are the second-leading cause of death worldwide. Six types of
                     diseases account for 80% of all deaths from infectious disease. Data from World Health Organization, 2009. World
                     health statistics 2009. WHO, Geneva, Switzerland.

                        In the United States and other developed nations, lifestyle   eat more. BPA exposure in mice has also been found to cause
                     trends are altering the prevalence of noninfectious disease in   blood insulin levels to be twice that of unexposed mice. This
                     ways both good and bad. In the last two decades, the percentage   excess of insulin can, over time, desensitize the body to insu-
                     of Americans who smoke cigarettes has dropped by 42%. But as   lin, leading to weight gain and type 2 diabetes.
                     we exercise less and eat fattier diets, the percentage of   Americans   Although infectious disease accounts for fewer deaths than
                     who suffer obesity has more than doubled (Figure 14.4).    noninfectious disease, infectious disease robs society of more
                     Surprisingly, elevated levels of BPA have been linked to obe-  years of human life, because it tends to strike people at all
                     sity. Studies have found that BPA exposure in mice elevates   ages, including the very young. The World Health Organization
                     the production of fat cells in developing embryos and leads   (WHO) estimates that of all the years of life lost to deaths each
                     to the storage of more fat in organisms, even if they do not   year, infectious disease takes 51%, whereas noninfectious dis-
                                                                          ease takes 34%. Decades of public health efforts have lessened
                        35%                                               the impacts of infectious disease and even have eradicated some
                                                                          diseases—yet other diseases are posing new challenges. Some
                      Prevelance in U.S. population  25%                  them (pp. 226–227). Others, such as tuberculosis and strains of
                        30%
                                                                          diseases, such as acquired immunodeficiency syndrome (AIDS),
                                                           Obesity
                               Smoking
                                                                          continue to  spread globally  despite concerted  efforts  to stop
                                                                          malaria, are evolving resistance to our antibiotics, in the same
                        20%
                                                                          way that pests evolve resistance to our pesticides (p. 273).
                        15%
                                                                          Social and environmental factors can
                        10%
                         5%

                          0                                               influence the spread of infectious disease
                                                                          In our world of global mobility and dense human populations,
                           1990  1993  1996  1999  2002  2005  2008  2011  novel diseases (and new strains of old diseases) that emerge in
                                               Year                       one location are more likely to spread to other locations, even
                     Figure 14.4 The prevalence of smoking has decreased in   worldwide. A pathogen can now hop continents in a matter of
                     the United States in the past 20 years, but obesity is on the   hours by airplane in its human host. As a result, some diseases
                     rise. Data from United Health Foundation, 2011. America’s health rankings,   have moved into new areas.
                     2011 edition. Minnetonka, MN.                           Recent examples include severe acute respiratory syn-
                           The population of the United States in mid-2011 was   drome (SARS) in 2003, the H5N1 avian flu (“bird flu”) start-
                           approximately 312 million people. Using the figure, estimate   ing in 2004, and the H1N1 swine flu that spread across the
             382     the number of Americans in 2011 who were (a) obese and (b) smokers.  globe in 2009–2010 (Figure 14.5). Diseases like influenza,







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