Page 154 - CSIR-IGIB Annual Report 2020-21

initiated in the states of Kerala and
Genomics and Genetic Epidemiology of Maharashtra, we aim to provide early warning
Emerging Infectious Diseases for emerging variants of SARS-CoV-2,
The emergence of SARS-CoV-2 as a global understand the emergence and dynamics of
pandemic and subsequent emergence of lineages and also aid in provision of evidence to
genetic variants associated with functional drive policy changes in the efforts to contain the
differences in infectivity as well as immune wayward spread of the pandemic.
escape has put genomics in the centrestage for The genomics efforts also provide insights into
the screening as well as genetic epidemiology of clinically curious cases like reinfections,
the virus. As part of the ongoing research in the breakthrough infections and rare re-activation
lab, we build computational resources and of SARS-CoV-2 through closely understanding
methodologies to understand the emergence of the genetic makeup of the virus in such
variants as well as to track them efficiently. As situations.
part of the genomic surveillance efforts now

Publications
A distinct phylogenetic cluster of Indian severe acute respiratory syndrome coronavirus 2 isolates. Banu S, Jolly B,
Mukherjee P, Singh P, Khan S, Zaveri L, Shambhavi S, Gaur N, Reddy S, Kaveri K, Srinivasan S, Gopal DR, Siva AB,
Thangaraj K, Tallapaka KB, Mishra RK, Scaria V, Sowpati DT. Open Forum Infect Dis. 2020 Sep 18;7(11):ofaa434.

Genomic analysis of patients in a south Indian community with autosomal dominant cortical tremor, myoclonus
and epilepsy suggests a founder repeat expansion mutation in the SAMD12 gene. Mahadevan R, Bhoyar RC,
Viswanathan N, Rajagopal RE, Essaki B, Suroliya V, Chelladurai R, Sankaralingam S, Shanmugam G, Vayanakkan S,
Shamim U, Mathur A, Jain A, Imran M, Faruq M, Scaria V, Sivasubbu S, Kalyanaraman S. Brain Commun. 2020 Dec
19;3(1):fcaa214.

Asymptomatic reactivation of SARS-CoV-2 in a child with neuroblastoma characterised by whole genome
sequencing. Yadav SP, Thakkar D, Bhoyar RC, Jain A, Wadhwa T, Imran M, Jolly B, Divakar MK, Kapoor R, Rastogi N,
Sharma D, Sehgal P, Ranjan G, Sivasubbu S, Sarma S, Scaria V. IDCases. 2021;23:e01018.

Genome-wide computational analysis and validation of potential long noncoding RNA-mediated DNA-DNA-RNA
triplexes in the human genome. Jalali S, Singh A, Scaria V, Maiti S. Methods Mol Biol. 2021;2254:61-71.

IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes. Jain A, Bhoyar RC,
Pandhare K, Mishra A, Sharma D, Imran M, Senthivel V, Divakar MK, Rophina M, Jolly B, Batra A, Sharma S, Siwach
S, Jadhao AG, Palande NV, Jha GN, Ashrafi N, Mishra PK, A K V, Jain S, Dash D, Kumar NS, Vanlallawma A, Sarma RJ,
Chhakchhuak L, Kalyanaraman S, Mahadevan R, Kandasamy S, B M P, Rajagopal RE, J ER, P ND, Bajaj A, Gupta V,
Mathew S, Goswami S, Mangla M, Prakash S, Joshi K, S S, Gajjar D, Soraisham R, Yadav R, Devi YS, Gupta A, Mukerji
M, Ramalingam S, B K B, Scaria V, Sivasubbu S. Nucleic Acids Res. 2021 Jan 8;49(D1):D1225-D1232.

DALIA- a comprehensive resource of disease alleles in Arab population. Vatsyayan A, Sharma P, Gupta S, Sandhu S,
Venu SL, Sharma V, Badaoui B, Azedine K, Youssef S, Rajab A, Fayez A, Madinur S, Ranawat A, Pandhare K,
Ramachandran S, Sivasubbu S, Scaria V. PLoS One. 2021 Jan 13;16(1):e0244567.

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