Page 17 - Labatt Brain Tumour Research Centre Annual Report 2022 to 2023

W
Integrated molecular and clinical characterization of disseminated paediatric low grade glioma: A paediatric low-grade glioma taskforce initiative. b.r.a.i.n.child
Investigating treatment targets in the DIPG immune landscape using single cell technology. Brain Tumour Foundation of Canada
LOGIC: Development of a complementary diagnostic for RRD detection. Ontario Genomics Institute, Genomic Applications Partnership Program (GAPP)
Investigating diffuse midline glioma evolution and treatment resistance. Canadian Institutes of Health Research
A phase 2 study of Trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathways. Canadian Institutes of Health Research
Investigating the role of oncohistones in cancer development. Canadian Cancer Society Research Institute
Molecular based approach for discovery and improved outcome for children and young adults with low grade glioma. Canadian Institutes of Health Research
Defining the role of the histone 3 (H3.3G34R) mutation in the pathogenesis of pediatric high- grade astrocytoma. Canadian Institutes of Health Research
Dr. Annie Huang
Defining therapeutic vulnerabilities in infant pineoblastoma. Pediatric Brain Tumor Foundation, USA
New mouse models and targeted therapies for aggressive forms of germline and sporadic pineoblastoma. Canadian Institutes of Health Research
Delineating mechanisms of cellular and phenotypic heterogeneity in ETMRs. Canadian Institutes of Health Research
Molecular basis of clinical heterogeneity in rhabdoid brain tumours. Canadian Institutes of Health Research
Targeting EZH2 in EBTs: Role of epigenetic modifiers in modulating pluripotency. Meagan’s HUG
(Meagan Bebenek Foundation)
Dr. Xi Huang
Identifying potassium channel modulators to target brain tumor-initiating cells. SickKids IP&C
Targeting fluidic force-sensing mechanism to tackle medulloblastoma metastasis. Meagan’s HUG (Meagan Bebenek Foundation)
Treating glioblastoma using an ion channel-targeting designer interference peptide. Canadian Cancer Society
Probing the multifaceted roles of reciprocal couplings between neuron and glioblastoma. SickKids Garron Family Cancer Centre Pitblado Discovery Grant
Treating chemoresistant glioblastoma by disrupting a potassium channel complex. b.r.a.i.n.child
Tissue stiffness heterogeneity in governing replicative potential and chemosensitivity of brain tumor-initiating cells. Cancer Research Society
Targeting potassium channel to disrupt the cellular hierarchy and suppress malignant growth of pediatric brain tumor. Canadian Institutes of Health Research
Establishing chloride intracellular channel CLIC1 as a therapeutic target for pediatric brain tumor. Canadian Institutes of Health Research
Bioelectrical signalling by ion channels in cell cycle.
Natural Sciences and Engineering Research Council
Dr. Jane McGlade
Approaches to regulate CBL ubiquitin ligase activity and control oncogenic tyrosine kinase signaling. Canadian Institutes of Health Research
Alternative splicing and Numb protein isoform function in cancer metastasis. Canadian Institutes of Health Research
Targetting cancer splicing programs to prevent metastatic progression. Canadian Cancer Society
GADS dependent signaling in BCR-ABL leukemia.
Cancer Research Society
Ubiquitin system regulation of epithelial polarity.
Natural Sciences and Engineering Research Council of Canada
17