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Contents

SECTION I: 17. Diagnostic Immunohistochemistry in
BASICS OF GYNAECOLOGICAL CANCERS Gyne-Oncologic Pathology:
A Βrief Appraisal of Common Applications . . . . . 163
1. History of Gynaecologic Oncology . . . . . . . . . . . . . . . 3
Elisabetta Kuhn, MD, Ayse Ayhan, MD, PhD
Krishnansu S. Tewari, MD, FACOG, FACS
Antonio Onnis, MD, Maria Marchetti, MD, Peter Bösze, MD 18. Pathology for Gynaecologic Oncologists . . . . . . . 171
Polat Dursun, MD, Murat Gultekin, MD, Ali Ayhan, MD
Suha Deen, FRCPath
2. Molecular Basis of Gynaecologic Cancers:
What Should we Know? . . . . . . . . . . . . . . . . . . . . . . . . 27 19. How to Report Pathology Specimens in
Gynaecologic Oncology . . . . . . . . . . . . . . . . . . . . . . . 176
Zvi Vaknin, MD, Walter H. Gotlieb, MD, PhD
Ayse Ayhan, MD, PhD
3. Genetics in Gynaecologic Oncology . . . . . . . . . . . . . 38
20. Role of Frozen Section in
Rachel Michaelson-Cohen, MD, Uziel Beller, MD Gynaecological Oncology . . . . . . . . . . . . . . . . . . . . . 185

4. Hereditary Women’s Cancer . . . . . . . . . . . . . . . . . . . . 42 Emanuela D’Angelo, MD, Anna Mozos, MD
Alberto Gallardo, MD, Jaime Prat, MD, FRCPath
Dan Reisel, MBBS, PhD, Lucy Side, MD, MRCP
Adam N. Rosenthal, PhD, FRCOG 21. Statistics for the Beginners in
Gynaecologic Oncology . . . . . . . . . . . . . . . . . . . . . . . 189
5. The Future of Cancer Stem Cells in
Gynaecologic Oncology . . . . . . . . . . . . . . . . . . . . . . . . 53 Alexia Iasonos, PhD

Karim S. ElSahwi, MD, FACOG, Alessandro D. Santin, MD SECTION II:
CERVICAL DISEASES AND HPV
6. Global Burden of Gynaecological Cancer . . . . . . . . 62
22. HPV Infection Epidemiology and Prevention . . . 195
Rengaswamy Sankaranarayanan, MD, Jacques Ferlay, ME
Alexandra de Pokomandy, MDCM, MSc
7. Prevention of Gynaecologic Cancers . . . . . . . . . . . . 75 Marie-Hélène Mayrand, MD, PhD

Satoru Sagae, MD, Nobuyuki Susumu, MD 23. HPV and Cervical Carcinogenesis . . . . . . . . . . . . . . 201
Aikou Okamoto, MD, Mitsuru Mori, MD
Antonios Anagnostopoulos, MD, John A. Green, MD, FRCP
8. Prognostic Factors for Gynaecologic Cancers . . . . 78
24. Human Papillomavirus Associated
Krista S. Pfaendler, MD, Okechukwu A. Ibeanu, MD, MPH Cancers Other Than Cervical Cancer . . . . . . . . . . . 207
Robert E. Bristow, MD, MBA
Lynette Denny, MD, PhD
9. Screening in Gynaecological Cancers . . . . . . . . . . . 85
25. The Spectrum and Clinical Sequelae of
Carmen Gan, MRCOG, Usha Menon, MD, FRCOG Human Papillomavirus Infection . . . . . . . . . . . . . . 214
Ranjit Manchanda, MD, MRCOG, PhD
Krishnansu S. Tewari, MD, FACOG, FACS
10. Circulating Tumor Markers in Bradley, J. Monk, MD, FACOG, FACS
Gynaecological Oncology . . . . . . . . . . . . . . . . . . . . . 100
26. Condylomas & Evidence-Based
Kunter Yuce, MD, Husnu Celik, MD Review of Medical and Surgical
Treatments of Genital Warts . . . . . . . . . . . . . . . . . . 223
11. Proteomics in Gynaecologic Oncology . . . . . . . . . 109
Eleonora P. Preti, MD, Ailyn Vidal, MD, Fabio Landoni, MD
Toon Van Gorp, MD, Isabelle Cadron, MD
Ignace Vergote, MD, PhD 27. HPV-Based Cervical Cancer Screening . . . . . . . . . 229

12. Ultrasonography in Gynaecological Cancers . . . 113 Karl-Ulrich Petry, MD, PhD, Chris J.L.M. Meijer, MD, PhD
Dorien C. Rijkaart, PhD, Johannes Berkhof, PhD,
Daniela Fischerova, MD, PhD Peter J.F. Snijders, PhD, Marc Arbyn, MD, MSc, DrTMH

13. Conventional CT and MRI in 28. New Technologies for
Gynaecological Malignancy . . . . . . . . . . . . . . . . . . . 130 Cervical Cancer Screening . . . . . . . . . . . . . . . . . . . . . 236

Nandita M. deSouza MD, FRCR Maribel Almonte, PhD, María de la Luz Hernández, PhD
Jack Cuzick, PhD
14. PET CT in Gynaecologic Oncology . . . . . . . . . . . . . 140
29. Bivalent HPV Vaccine Approved for
Perry W. Grigsby, MD Cervical Cancer Prevention in Females . . . . . . . . . 247

15. Functional Imaging for Measuring Luz M. Fernandez, MD, M. Eli Pendleton MD
The Response to Treatment . . . . . . . . . . . . . . . . . . . 143 R. Brent Wright, MD, MMM, Diane M. Harper, MD, MPH, MS

Ioanna Papadopoulou, FRCR 30. Quadrivalent and Nonavalent HPV Vaccine
Andrea G. Rockall, BSc, MBBS, MRCP, FRCR Approved for Males and Females for HPV
Alexandra Taylor, MBBS, MD Associated Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . 279
Tara D. Barwick, MBChB, MSc, MRCP, FRCR
A. Scott LaJoie, MSPH, PhD, Luz M. Fernandez, MD
16. Imaging-Guided Interventions in M. Eli Pendleton, MD, Diane M. Harper, MD, MPH, MS
Gynaecologic Oncology . . . . . . . . . . . . . . . . . . . . . . . 157

Michal Zikan, MD, PhD

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