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innovation and technology

Fig. 3. First-generation nanotherapeutics.

from the Nanotherapeutics Lab (NTL) has been progressing well in the development of new
generation anticancer nanotherapeutics and nano-drug-carriers for active and passive tumour
delivery of anticancer drugs and imaging probes. Some of the notable products developed
by the team include high-drug-payload nanotherapeutics, immuno-stealth-nanotherapeutics,
free-radical-generating near-Infrared (NIR)-photodynamic nanotherapeutics, photothermal
nanotherapeutics, etc. Although good progress is seen in the nanotherapeutics research both
from within UM and respective institutions across Malaysia, greater investments from the
public and private sectors are still very much needed not just to further excite the growth of
the field, but also to encourage coalition among the local research groups and companies for
greater advancements.

References:
1. McWilliams, A., Global Markets for Nanocomposites, Nanoparticles, Nanoclays, and Nanotubes. NAN021G,
Global Markets, BBC Research Report Jan 2017.
2. Kiew, S. F.; Ho, Y. T.; Kiew, L. V.; Kah, J. C. Y.; Lee, H. B.; Imae, T.; Chung, L. Y., Preparation and characterization
of an amylase-triggered dextrin-linked graphene oxide anticancer drug nanocarrier and its vascular
permeability. International Journal of Pharmaceutics 2017, 534 (1-2), 297-307.
3. Voon, S. H.; Tiew, S. X.; Kue, C. S.; Lee, H. B.; Kiew, L. V.; Misran, M.; Kamkaew, A.; Burgess, K.; Chung, L.
Y., Chitosan-Coated Poly(lactic-co-glycolic acid)-Diiodinated Boron-Dipyrromethene Nanoparticles
Improve Tumor Selectivity and Stealth Properties in Photodynamic Cancer Therapy. Journal of Biomedical
Nanotechnology 2016, 12 (7), 1431-1452.
4. Cheah, H. Y.; Gallon, E.; Dumoulin, F.; Hoe, S. Z.; Japundžić-Žigon, N.; Glumac, S.; Lee, H. B.; Anand, P.; Chung,
L. Y.; Vicent, M. J.; Kiew, L. V., Near-Infrared Activatable Phthalocyanine–Poly-L-Glutamic Acid Conjugate:
Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy.
Molecular pharmaceutics 2018, 15 (7), 2594-2605.
5. Saw, W. S.; Ujihara, M.; Chong, W. Y.; Voon, S. H.; Imae, T.; Kiew, L. V.; Lee, H. B.; Sim, K. S.; Chung, L. Y.,
Size-dependent effect of cystine/citric acid-capped confeito-like gold nanoparticles on cellular uptake and
photothermal cancer therapy. Colloids and surfaces. B, Biointerfaces 2018, 161, 365-374.

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