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DURABILITY OF A LOW SHRINKAGE




       TEGDMA/HEMA-FREE RESIN





       COMPOSITE SYSTEM IN CLASS II




       RESTORATIONS.











                                                                                                                               marketed during the last years 10–12 .   high hydrophilicity and detergent   HEMA in adhesives may lead to
        DESPITE THE INCREASING USE OF RESIN COMPOSITES,                                                                        Biocompatibility of dental materials   activity in liposomes. It can penetrate   phase separation between water
                                                                                                                               is an important consideration for    all biologicalcompartments, the      and the adhesive monomers  27–29 . It
        THERE ARE STILL SEVERAL REMAINING PROBLEMS TO BE SOLVED.                                                               the patient and clinician. Many in   extracellular and intracellular space,   has been shown that HEMAinhibited
                                                                                                                                                                                                         intracellular tyrosine phosphorylation
                                                                                                                                                                    including cell nuclei and membranes.
                                                                                                                               vitro studies have shown that the
                                                                                                                               polymerization reaction, producing   The monomer showed chemical–         20] , induced cell growth inhibition and
                                                                                                                               the cross-linked polymer matrix from   biological interactions with many   cycle perturbation   and is a potent
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                                                                                                                               the dimethacrylate resinmonomers, is   cell structures or processes like   inducer of apoptotic cell death  .
                                                                                                                               never complete. It has been reported   inhibition of cell growth and decrease   Cell mutation has been observed
                                                                                                                               that of the methacrylate groups,     of the intracellular glutathione level   after exposure to both TEGDMA
            he objective of this            estimated. Results. Three molar teeth   cross-linking of the polymer chains.       25%–60% may remain unreacted and     18,19,21,22 . The quantity of TEGDMA   and HEMA 32,33  as well as increased
            randomized controlled           showed mild post-operative sensitivity   The free curing contraction for           about 10% of the available groups    leaching from restorative materials   intracellular concentrations of
       Tprospective trial was to            during 3 weeks for temperature       resin composites varies from1.0%              are free to diffuse out in the oral   is predominantly dependent on the   reactive oxygen species (ROS)  22,34 .
       evaluate the durability of a low     changes and occlusal forces. After 6   to 5.0%  . In the pre-gel phase, the        cavity 13,14 . Adverse reactions may   monomer–polymer conversion. But    Exposure to low con-centrations of
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       shrinkage and TEGDMA/HEMA-free       years, 134 Class II restorations were   material is able to flow and stresses      be expected in sensitive operators   in addition, chemical processus      the monomers for a prolonged time
       resin composite system in posterior   evaluated.Twenty-one restorations,   are relieved. Post-gel polymerization        or patients due to the release of    like erosion, enzymatical hydrolytic   reduced the rate of cell proliferation
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       restorations in a 6-year follow up.  8 cmf-els (11.4%) and 13 ASE-els     results in stresses in the material           non-polymerized monomers. Clinical   disintegration and alcoholysis as    possibly as result of DNA damage .
         Methods. 139 Class II restorations   (20%) failed during the 6 years (p   and tooth structures and their              studies have shown that dental resin   well as physical processes like wear   In addition it has been observed that
       were placed in 67 patients with a    < 0.0001). The annual failure rates   interfaces, which may affect the             composites may induce local and      may also contribute to a release     TEGDMA and HEMA are common
       mean age of 53 years(range 29–82).   were 1.9% and 3.3%, respectively.    interfacial adaptation and durability         systematic adverse effects, which    of degradation products from the     sensitizers with a high sensitizing
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       Each participant received at random   The main reasons for failure were   of restorations  2–6 . The magnitude          are caused by methacry-late (co)     polymerized resin in time  . Geurtsen   potential 36–38 . The lower the molecular
       two, as similar as possible, Class II   fracture followed by recurrent caries.   of shrinkage stress depends on         monomers  . Two frequently used      and Leyhausen   concluded that it    weight of the monomer, the higher
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       restorations. In the first cavity of each   Most fractures and all caries lesions   many factors like resin matrix      methacrylatemonomers TEGDMA          should be the aim of future studies   the biophase penetration risk and
       pair the TEGDMA/HEMA-free resin      were found in high risk participants.  formulation, amount of filler used in       (Triethyleneglycol-dimethacrylate)   to replace TEGDMA with more          allergic potential.The risk of allergic
       composite system was placed with     Significance. The Class II resin     the resin composite and degree of             andHEMA (2-hydroxyethyl-             biocompatible diluentmonomers.       reactions increases due to unwary
       its 3-step etch-and-rinse adhesive   composite restorations performed     conversion. Cuspal movement during            methacrylate) eluate from different   HEMA is frequently present in dental   handling of the non-cured resin
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       (cmf-els). In the second cavity a1-  with the newTEGDMA/HEMA-free low     polymerization may be perceived as            resin composites, compomers,         adhesives, resin-modified glass      monomers  . Fast penetration of
       step HEMA-free self-etch adhesive    shrinkage resin composite system     post-operative pain 7–9 . Increasing          resin modified glass ionomers and    ionomers and poly-acid modified resin   uncured monomers through the skin
       was used (AdheSe One F). The         showed good durability over six years.  C-factor may result in greater stresses    adhesives and have been shown        composites. In adhesives, in amounts   and gloves cause contact dermatitis
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       restorations were evaluated using                                         due to the larger number of bounded           to be responsible for several        from 30% to 55%, it reduces viscosity,   in dental staff  . Patients with
       slightly modified USPHS criteria at   INTRODUCTION                        surfaces. Posterior Class I and II            cytotoxic reactions  16–20 . The     promotes diffusion of co-monomers    diagnosed allergies for HEMA and/
       baseline and then yearly during 6    During curing of themonomers, a      cavities will therefore show high stress      diluent monomerTEGDMA show           by expanding the demineralized       or TEGDMA should not receive dental
       years. Caries risk and parafunctional   network of polymers is formed, which   formation. A few low shrinkage resin     biological significant properties,   collagen  24–26  and enhances bond   materials which can release these
       habits of the participants were      becomes rigid due to increasing      composites have been developed and            like low molecular weight, relatively   strength to dentin  . Omission of   monomers. Recently a TEGDMA/
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       26  WORD OF MOUTH      SUMMER 18/19                                                                                                                                                            WORD OF MOUTH      SUMMER 18/19   27
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