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Variables in Clinical and Preclinical Modeling
Murine Tumor Models Clinical Cancer PLaifteiePnhatse in Human and Mice
• Vary but generally >55 years old
• Increasingly obese
• 8-12 weeks old (equivalent to a young adult)
• Lean
Aged Mice Have Markedly Increased Body Weights and Adiposity Compared to Young Mice
4 mo 15 mo
water suppression ( fat is bright)
fat suppression (fat is dark/black).
Mirsoian A et al. J Exp Med. 2014.
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