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• Don’t consume grapefruit or grapefruit juice with
medications 33
A substance found in grapefruit and its juice can alter the effects
of several drugs, sometimes causing a buildup of medication, which
could become toxic One example is atorvastatin (Lipitor), which is
used for high cholesterol
• Avoid alcohol
Alcohol can increase or reduce a drug’s effects or increase side
effects
• Don’t take a vitamin and mineral supplement or
antacids at the same time as your medication unless
your doctor approves
Some nutrients can bind with drug ingredients, reducing their
absorption and limiting their effectiveness
• Tell your doctor if you’re taking dietary supplements

Many herbal and other dietary supplements have known interactions
with medications, and others haven’t been thoroughly tested for
interactions While you’re on medications, check with your doctor
or pharmacist before adding supplements
• Take medication as recommended
Some drugs are better absorbed with food to reduce the risk of
stomach irritation or upset Other drugs may be better absorbed
when taken with a full glass of water an hour or two before meals
Follow your doctor’s or pharmacist’s instructions

30 Mayo Clinic