Page 10 - “Las complicaciones en la coagulación y deficiencia de plaquetas en pacientes con COVID- 19”

Abstract

Complications in coagulation and

platelet deficiency in patients with

COVID-19

Today, doctors have found that one of the most common complications worrisome
of Covid 19, is the unusual formation of blood clots in numerous patients, including
those who were receiving anticoagulants. This large number of clots can reach

organs such as the lung, heart, or brain, and cause heart attacks or accidents

cerebrovascular disease (CVA), with fatal consequences. This review allows capture
aspects related to coagulation disorders present in patients with Covid 19. Regarding

the results, the presence of coagulopathy in patients with Covid 19 has promoted

the approach of antithrombotic strategies. Blood thinners taken by mouth,
subcutaneousn or IV can play an important role in the care of patients with Covid-19

and these can prevent possible fatal events associated with coronavirus, including

heart attack, accident cerebrovascular and pulmonary embolism. There is a long way
to go in research of Covid 19, so it is necessary when establishing a treatment for

coagulation disorders, consider both the clinical situation of the patient and the
presence of comorbidities in order to assess both the risk thrombotic such as

hemorrhagic.

It is known that covid-19 can affect all the patient's systems and that inflammation
is a common reaction in serious people in their struggle against infection. SARS-CoV-

2 is shown to trigger changes genetics in blood platelets, which could be a factor

contributor to the occurrence of heart attacks, strokes and other serious
complications, In various studies with COVID-19 patients, only 5% of patients had

platelet count below 100 x 109 cells / L. But nevertheless Mild thrombocytopenia

(count <150 x 109 cells / L) may be seen in 70% or 95% of patients with severe
COVID-19. Average fibrinogen concentrations in patients with COVID-19, are at the

upper limit of normality, possibly in the context of the acute phase reaction
However, in a number of China reported a sharp decrease in plasma fibrinogen

levels to <1 g / l immediately before death. Plasma antithrombin levels are lower in
8 COVID-19 subjects who die, compared to the survivors; however, serum levels

rarely fall below.