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Muscle contratction inc contractibility inc ventricular ejection

dec end systolic and diastolic inc cardiac output and renal dec compensatory renal and
volume profusion sympathitic response

permit heart to
decrease heart rate, preload function more
and afterload
efficiently

Electrical effects

Early response (parasympathetic effects)

 Inc PR interval  due to decrease AV conduction velocity

 Flattening of T wave

Toxic effects

+2
 Inc automaticity caused by intracellular Ca overload

 Premature ventricular beats

Clinical Uses of cardiac glycosides

Cardiac glycosides
Contents C  congestive cardiac failure

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman