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 Inc. mucosal protection

 Dec. acid secretion

Uses

 Effective in Ulcers by NSAIDS

Not used widely because of multiple doses and poorly tolerated adverse

effects

Side effects diarrhoea + GIT upset

 Should not be taken by pregnant women  increase uterine

contractions may cause abortion

 With mifepristone used vaginally  to terminate pregnancy

Sucralfate

 Aluminium sucrose sulphate

o Poorly soluble molecule that polymerise in acidic
environment of stomach and bind to injured tissue

 form protective covering over ulcer beds

 accelerate healing of the ulcer

 Reduce reoccurrence rate

o Systemic effects are very less  too insoluble

 Toxicity very low

Colloidal bismuth

 Formation of protective covering on the ulcerative tissue

 Stimulation of mucosal protection mechanism

Antibiotics

Chronic infection with H-Pylori (present in most of the patients with
Contents reoccurrence, Non NSAID induced peptic ulcer.

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman