Page 180 - Pharmacology Mnemonics and Short Notes

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E  esmo + prazole  Esmoprazole

R  Rabe + prazole  Rabeprazole

Mechanism

Lipophilic weak bases that diffuses into parietal cell canaliculi.

 Irreversibly inhibit the parietal cells H/K ATPase the transporter

that is primarily responsible producing stomach acid.

Uses

In GERD and peptic ulcer these agents are more potent than H 2 receptor
antagonists

Pharmacokinetics

 Oral formulations are enteric coated to prevent destruction in

stomach

 Half-life of 1-2 hours and effects last for 1 day and 3-4 days are
required to achieve full effectiveness

Adverse effects

TIDA proton

T  Vit B twelve (B 12) deficiency  because of decrease
Contents absorption (need acidity for absorption)

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman