Page 272 - Pharmacology Mnemonics and Short Notes

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antiestrogens

Aromatase
Receptor inhibitors Others
inhibitors

full

antagonists SERMs anastrazole Danazole

fulvestrant tamoxifen

Fulvestrant

Estrogen receptor antagonist in all tissues

Full receptor antagonist  full  fulvestrant

Use

 Adjuncts in hormone responsive breast cancer fail to response first line
antiestrogen therapy

Adverse effects

 Hot flushes + headache

SERMS  selective estrogen modulators

Tamoxifen

 Estrogen action in breast tissue and CNS

 Agonist effects in liver and bone

Uses

Contents  Prevention and treatment of responsive breast cancer

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman