Page 273 - Pharmacology Mnemonics and Short Notes

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Adverse effects

 Hot flushes

 Endometrial hyperplasia

 Thromboembolism

Tormifene  same as tamoxifen

Raloxifene  for osteoporosis and breast cancer prevention

Clomiphene

 Induces ovulation  used in fertility

Anastrazole

Reduce estrogen synthesis by inhibition of aromatase enzyme

Aromatase  A  anastrazole

Use

 Adjuncts in hormone responsive breast cancer

Adverse effects

 Hot flushes

 Decrease bone mineralization

 Joint problems (arthralgia, arthritis etc.)

Danazole

Inhibit cyt P450 weakly and act as gonadotropin receptor antagonist

GnRH agonist  Danazole

Uses

 Endometrial fibrotic breast disease

Adverse effects
Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman