Page 292 - Pharmacology Mnemonics and Short Notes

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Penase inhibitors

 Inhibit penicillinases enzyme  salbactam, tazobactum and clavulanic

acid

Toxicity

 Allergic reactions (SAAF)

o S  joint swelling

o A  Hemolytic anemia

o A  Anaphylaxis

o F  fever

 GIT disturbances

Naficillin  N  neutropenia

Ampicillin  AM  allergic reaction maculopapular skin rash

Cephalosporins

Derivatives of 7-amiocephalosporanic acid

Mechanism

 Bind to penicillin binding proteins (PBPs)  similar to penicillin (But
structure is different from penicillin)

Resistance

Contents  Decrease in membrane permeability

 Change in structure of PBPs

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman