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 Inhibition of transpeptidation reaction (cross linking of peptidoglycans
is inhibited)

 Produce lesions in bacterial cell wall by activation of autolytic enzymes

Mechanism of resistance

 Formation of beta lactamases (penicillinases)

 Structural changes in penicillin binding proteins (PBPs)

 Changes in porin structure in outer cell wall

Narrow spectrum

 Penase susceptible(Penase  penicillinases)

Mean penase is working here so Drugs will be with P

P  Penicillin G

P  Penicillin V  oral drug mainly used in oropharyngeal infections

Spectrums

o Gram (+)  streptococci

o Gram negative cocci (-)  Neisseria

o Spirochetes

 Penicillin  no Longer suitable for Gonorrhoea

 For syphilis  first line of treatment

 Penase resistant

Means drug is resistant to penase enzyme  enzyme have NO action

on drug

N  Naficillin

O  Oxacillin

Contents Spectrum

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman