Page 118 - Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine

Klingeborn et al. Page 23

RPE retinal pigmented epithelium
CNV choroidal neovascularization

FasL Fas ligand

ECM extracellular matrix

LC lamina cribrosa
TM trabecular meshwork
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MMPs matrix metalloproteinases

AMD age-related macular degeneration

ApoE apolipoprotein E
PCP protein correlation profiling

AH aqueous humor

PEG polyethylene glycol

VEGF vascular endothelial growth factor
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PEDF pigment epithelium-derived factor
fn fibronectin

dex dexamethasone

Glossary

Apoptotic bodies or blebs
Large portions (1–5 microns) of cells undergoing apoptosis which are released into the
extracellular milieu by blebbing from the plasma membrane

Ectosome
Sometimes used to indicate neutrophil- or monocyte-derived MVs specifically, sometimes
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used to indicate MVs from any cell type

Endosome
Membrane-bound compartment inside eukaryotic cells. It is a compartment of the endocytic
membrane transport pathway originating from the trans-Golgi membrane

ESCRT
Endosomal sorting complexes required for transport (ESCRT). Are made up of cytosolic
protein complexes ESCRT-0 through –III

Exosome
Smallest subset of EVs. Of endolysosomal origin and released to extracellular milieu upon
fusion of MVE with plasma membrane
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Prog Retin Eye Res. Author manuscript; available in PMC 2018 July 01.