Page 119 - Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine

Klingeborn et al. Page 24

Extracellular vesicle (EV)
Any lipid bilayer vesicle released from the cell in a controlled manner in an approximate
size range of 30–1,000 nm. Does not include apoptotic blebs/bodies

Invadopodia
Newer, broader term replacing the terms invados ome, podosome and PILS

Invadosome, podosome, PILS
Any of several actin-rich adhesion structures. Podosome or invadopodia-like structures
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(PILS)
Lipoprotein particle
HDL, LDL, VLDL & Chylomicrons. Particles containing lipids, cholesterol and
apolipoproteins

Lysosome
Organelle with an acidic interior containing a large range of digestive enzymes used
primarily for digestion and removal of excess or damaged organelles, proteins, and engulfed
viruses or bacteria

Multivesicular endosome (MVE)
ESCRT complexes generate exosomes by a controlled inward budding process from the
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endosome membraneresulting in an MVE

Microparticle, microvesicle (MP, MV)
EVs budding directly from the plasma membrane into the extracellular milieu. Approximate
size range 150–1,000 nm

Proteasome
A multisubunit enzyme complex that plays a central role in the degradation of proteins that
have been tagged by ubiquitin

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Prog Retin Eye Res. Author manuscript; available in PMC 2018 July 01.