Page 30 - BB Neuromedicine Highlights 2019
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Over 100 million Amer-      dition to new antibody therapies,
        icans are affected by       hold great promise for the future.
        a kind of neurological      a BOlD NeW WOrlD – sTem
        illness. Such conditions    cells aND geNe TheraPIes
        result in over $800 billion   the use of stem cells in neuro-
        in annual costs. Likewise,   science continues to advance rap-
                                    idly. By using stem cells, defective
        over 40 million in the U.S.   cells causing a disease may be re-
        suffer from mental illness   placed allowing better functional
        or psychiatric disease.     abilities. Alternatively, stem cells
                                    can be used in neuromedicine to
        The impact of psychiatric   protect function by adding cells
        diseases is similarly pro-  that compensate for faulty ones.
        found, affecting not only   Stem cell treatments are being
        individuals but families    explored actively in neuroscience
                                    for conditions like Parkinson’s
        and society at large.       disease and ALS.
                                     Notably, gene therapies and
          Together, these conditions   precision medicine are making
        comprise the field of neuromed-  huge impacts in other areas of
        icine. However, neuroscience   healthcare. The same will apply
        offers tremendous hope. Rapidly   to neuromedicine as well. For
        advancing neuroscience technol-  example, genes may be turned
        ogies promise an array of new   “off” or altered to treat neuro-
        diagnostics and interventions that   logical disorders like epilepsy and
        could dramatically change neu-  neuromuscular disease. genome
        romedicine of the future.  Bold   projects are also identifying a
        leaders in the neuromedicine field   number of new biomarkers for
        plan to make this a reality sooner   neuromedicine conditions. These
        than later.                 advances will permit earlier
                                    detection of risk or disease that
        aDvaNces IN ImmuNOlOgy      can better prevent or slow onset
        aND NeurOscIeNce            of illness.
          Two renowned scientists have
        received this year’s Nobel  Prize   PIcTures are WOrTh a ThOu-
        in physiology or medicine. their   saND cures – NeurOImagINg
        discoveries of immune checkpoint   DevelOPmeNTs
        proteins revolutionized cancer   For decades, neuroimaging ad-
        treatments through focused   vances have radically changed the
        antibody therapies. These same   practice of neuromedicine. The
        techniques have already advanced   future of neuromedicine will see
        care for brain cancers within   more of the same in this regard.
        neuromedicine today. neurosci-  Currently, the combination of
        ence, however, has other notable   high-resolution MRI with function-
        immune system advances as well.  al tracers using pEt scan or other
          For example, neuromedicine   techniques is revealing bold new
        research is exploring the link be-  insights. new neuroscience has
        tween organisms in our intestinal   evidence about poorly-defined
        tract and our brain’s functioning.   conditions like schizophrenia and
        Our intestines are home to 80   fibromyalgia and how they are
        percent of our immune system.   being exposed through these
        This area of neuromedicine, in ad-  techniques.
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