Page 29 - Laboratory manual for students FAR222 2019 20

FAR 222 Dosage Form II Laboratory Manual

5. Borate Buffer (pH range 6.8 to 9.1)

Sodium chloride required for
pH Boric acid (g/L) Borax (g/L)
isotonicity (g/L)
6.8 12.03 0.57 2.7
7.2 11.66 1.15 2.7
7.4 11.16 1.91 2.7
7.7 10.54 2.87 2.6
7.8 9.92 3.82 2.6
8.0 9.30 4.78 2.5
8.1 8.68 5.73 2.4
8.2 8.06 6.69 2.3
8.4 6.82 8.60 2.1
8.6 5.58 10.51 1.9
8.7 4.96 11.46 1.8
8.8 3.72 13.37 1.4
9.0 2.48 15.28 1.1
9.1 1.24 17.20 0.7

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