Page 187 - Wasserstoff Medizin

the total transport of these species; both hydrogen ions and carbon dioxide are also
transported in the blood as bicarbonate (HCO3-), formed spontaneously or through
the action of carbonic anhydrase.

Sodium bicarbonate (baking soda) is the stunning medicine it is because it puts doctors’
and patients’ fingers on the CO2 pulse of the body. Bicarbonate intake raises the CO2
levels in the blood. CO2 is a key regulator of inflammatory reactions due to control
of cells oxygen supply. Bicarbonate also regulates inflammatory reactions due to rapid
changes in tissue and fluid pH.

In all serious disease states we find a concomitant low-
oxygen state. Low oxygen in the body tissues is a sure
indicator for disease. Hypoxia, or lack of oxygen in the
tissues, is the fundamental cause for all degenerative disease.
Dr. Stephen Levine
Molecular Biologist

In order to survive, the body must maintain proper acid/alkaline (pH) balance because
when it does not do so, tissue oxygen levels suffer. The optimum (and required) pH of
the blood is somewhat alkaline, between 7.35 and 7.45. Only in this range is the blood
richly supplied with oxygen.

Oxygen, Inflammation & Hypoxia-Inducible Factor (HIF-1)

Scientists in Germany have shown that the microenvironment of inflamed and injured
tissues are typically characterized by low levels of oxygen and glucose, and high levels
of inflammatory cytokines, reactive oxygen, and nitrogen species and metabolites.
Medical research has suggested that there is a strong link between cell hypoxia (oxygen
deficiency in cells) and chronic inflammatory processes.

Inflammation is the most common causes of tissue hypoxia and/or decreased
circulation. Inflammation can lead to sepsis, circulatory collapse and ultimately multi-
system organ failure.

Tissue hypoxia is manifested in increased levels of hypoxia-inducible factor (HIF-1) (this
factor and cell hypoxia are key factors in the progress of cancer). Elevated HIF-1 triggers
a cascade of events, with involvement of pro-inflammatory transcription factors such
as nuclear factor kappa B (or NF-kappaB) and activator protein AP-1.

When oxygen levels fall things get dangerous on a cell level because at low levels gene
expression changes. HIF-1a regulates the expression of at least 30 genes when oxygen
levels are low.

Cancer & HIF-1

“Radiation and chemotherapy do kill most solid tumor cells, but in the cells that survive,
the therapies drive an increase in HIF-1, which cells use to get the oxygen they need by

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