Page 184 - Wasserstoff Medizin

Oxidative stress is obvious in chronic hepatitis B (CHB) patients, with liver function
normally being significantly impaired. After hydrogen-rich water treatment (1200-1800
mL/day, twice daily) liver function was improved significantly. Hydrogen-rich water
xvi
significantly attenuates oxidative stress in CHB patients.

Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is
reportedly associated with peritoneal deterioration in patients treated with peritoneal
dialysis (PD). Effluent and blood samples of 6 regular PD patients were obtained during
the peritoneal equilibrium test using standard dialysate and hydrogen-enriched dialysate.
Mean proportion of redd albumin in effluent was significantly higher in H2-enriched
dialysate than in standard dialysate. Likewise, serum ƒ(HMA) after administration of
hydrogen-enriched dialysate was significantly higher than that after standard dialysate.
Trans-peritoneal administration of H2 reduces peritoneal and systemic oxidative stress. xvii

Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis and
therapeutic approaches are limited. Changes in dialysis parameters showed significant
decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and
myeloperoxidase (P < 0.05) when even low concentrations of hydrogen water were used.
Adding molecular hydrogen to haemodialysis solutions ameliorated inflammatory
reactions and improved BP control. Hydrogen offers a novel therapeutic option for
control of uraemia. xviii

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