Page 303 - Bloedstollig en bloedingsneiging

‘Some will say, as they always have said, that these factors, co-factors, activa- tors and inhibitors are probably artefacts or mere figments of the imagination. All but one of the clotting factors have, by simple absence from the blood, produced specific haemorrhagic diatheses in man.’
R.G. Macfarlane (n.d.); geciteerd in J.G.G. Schoenmakers (1965)1
‘... bibliometrisch meten leidt tot conservatisme. Dat doet het AMC ook en dat leidt tot heel veel frustratie; maar ook leidt het tot ‘de dood in de pot’. Waar- om? Een dergelijke structuur houdt in dat je wel heel dom moet zijn om van vakgebied te veranderen! Je staat in dat geval de eerste tijd ‘droog’ voor wat betreft publicaties. Je productiviteit keldert.’
Hans Pannekoek (2014)2
‘Most of the readers of this review were probably taught about hemostasis using a modification of the coagulation cascade or ‘waterfall’ models propo- sed in the 1960s. These models were major conceptual advances, because they proposed the concept that a series of proteolytic reactions could act as a biologi- cal amplifier - a paradigm now well recognized to underlie many physiological processes. [... The coagulation scheme] was not actually proposed as a literal model of the hemostatic process in vivo. However, the lack of any other clear and predictive concept of hemostasis meant that most physicians and students of coagulation de facto viewed the cascade as a model of physiology.’
Dougald M. Monroe en Maureane Hoffman (2005)3
‘Researchers tend to work in silos and are often unaware of the important dis- coveries made next door to them.’
Jack Hirsh (2014)4
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