Page 19 - CBAC Newsletter 2016

Reference List

1. Cooper EC., Jan LY. Ion channel genes and human neurological disease: recent progress, prospects, and
challenges. Proc Natl Acad Sci USA. 96: 4759-4766, 1999.
2. Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease.
Nat Rev Neurosci. 1: 21-30, 2000.
3. Rogawski MA. KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications

for therapy. Trends Neurosci. 23: 393-398, 2000.
4. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronen GM, Bjerre I, Quattlebaum T, Murphy JV.,
McHarg ML., Gagnon D, Rosales TO, Peiffer A, Anderson VE, Leppert M. A novel potassium channel gene,
KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet. 18: 25-29, 1998.
5. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K,

Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M,
Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M,
Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS; International Union of
Pharmacology. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels:
potassium channels. Pharmacol Rev. 55: 583-586, 2003.
6. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ. KCNQ4, a novel
potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.
Cell. 96: 437-446, 1999.
7. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ. KCNQ5, a novel potassium channel broadly
expressed in brain, mediates M-type currents. J Biol Chem. 275: 24089-24095, 2000.
8. Wang Q, Curran ME, Splawski I., Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM,
de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT. Positional
cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Nat Genet. 12: 17-23, 1996.
9. Osteen JD, Sampson KJ, Kass RS. The cardiac IKs channel, complex indeed. Proc. Natl. Acad. Sci. USA.
107: 18751-18752, 2010.
10. Robbins J. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther.
90: 1-19, 2001.
11. Shapiro MS, Roche JP, Kaftan EJ, Cruzblanca H, Mackie K, Hille B. Reconstitution of muscarinic modulation of
the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current. J Neurosci. 20: 1710-1721, 2000.
12. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D. KCNQ2 and KCNQ3
potassium channel subunits: molecular correlates of the M-channel. Science. 282: 1890-1893, 1998.
13. Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M. Potassium channels: molecular defects, diseases, and
therapeutic opportunities. Pharmacol Rev. 52: 557-594, 2000.
14. Hu H, Vervaeke K, Storm JF. Two forms of electrical resonance at theta frequencies, generated by M-current,
h-current and persistent Na+ current in rat hippocampal pyramidal cells. J Physiol. 545: 783-805, 2002.
15. Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D. Conditional transgenic suppression of M channels in mouse
brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci. 8: 51-60, 2005.
16. Vervaeke K, Gu N, Agdestein C., Hu H., Storm JF. Kv7/KCNQ/M-channels in rat glutamatergic hippocampal
axons and their role in regulation of excitability and transmitter release. J. Physiol. 576: 235-256, 2006.
17. Yu H, Wu M, Townsend SD, Zou B, Long S, Daniels JS, McManus OB, Li M, Lindsley CW, Hopkins CR. Discovery,

Synthesis, and Structure Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides:
Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.
ACS Chem Neurosci. 2: 572-577, 2011.
18. Yue C, Yaari Y. KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal
neurons. J. Neurosci. 24: 4614-4624, 2004.

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