Page 3 - Cardiac Electrophysiology | A Modeling and Imaging Approach

CONTENTS

1. Prologue........................................................................................................................................................................................p.5

2. The Cardiac Ventricular Action Potential............................................................................................................p.7

2.1 Computing the Action Potential from Macroscopic Transmembrane Currents.............p.7

2.2 Computing the Action Potential from Ion Channels Kinetic Properties..............................p.9

2.3 Generation of an Action Potential by the Cardiac Cell.....................................................................p.11

2.4 Rate Dependence of the Action Potential...............................................................................................p.13

2.5 Kinetics of Selected Ion Channels During the Action Potential................................................p.16

2.6 The Human Ventricular Myocyte..................................................................................................................p.26

2.7 The Purkinje Cell......................................................................................................................................................p.32

2.8 Structure-Function Relationship of an Ion Channel During Gating......................................p.50

2.9 Linking Ion-Channel Mutations to the Whole-Cell Electrophysiological
Phenotype...................................................................................................................................................................p.59

2.10 Beyond Rate-Adaptation: Action Potential Alternans.....................................................................p.61

2.11 Regulation of Cellular Calcium Cycling and Electrophysiological Processes...................p.65

2.12 Calcium Cycling in Ventricular Myocytes: Macroscopic Consequences of
Microscopic Dyadic Function..........................................................................................................................p.71

3. Propagation of the Cardiac Action Potential..................................................................................................p.71

3.1 Basic Biophysical Principles..............................................................................................................................p.71

3.2 Discontinuous Conduction...............................................................................................................................p.73

3.3 The Ionic Mechanisms of Conduction........................................................................................................p.81

3.4 Propagation in the Wake of a Cardiac Action Potential................................................................p.95

3.5 Ion Channels Heterogeneities and Action Potential Propagation.........................................p.98

3.6 Dynamics of Reentry in a Fixed Pathway..............................................................................................p.102

3.7 Propagation in Higher Spatial Dimensions..........................................................................................p.106