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SCIENCEMonday 26 October 2015

Plague spread 3,000 years earlier than 1st thought: 2,800 BC 

MARIA CHENG                     In this undated photo released by Cell journal, the Sope I grave in Estonia, where plague DNA                                    half of Europe, the Bronze
Associated Press                was found in a tooth from this individual and is the earliest evidence of plague found in Europe.                                Age plague revealed by
LONDON (AP) — The               The plague was spreading nearly 3,000-years before previously thought, according to findings                                     the new study could not
plague was spreading            published Thursday Oct. 22, 2015, in the journal Cell.                                                                           be spread by fleas be-
nearly 3,000 years before                                                                                                                                        cause it lacked a crucial
previously thought, scien-                                                                                                     (Harri Moora / Cell 2015 via AP)  gene. So it was probably
tists say after finding traces                                                                                                                                   less able to infect people
of the disease in the teeth     it was supposed to exist,”   Rasmussen said the plague    Black Death that swept                                                 over wide regions. But Ras-
of ancient people — a dis-      said Rasmussen, one of the   they found was a different   across Medieval Europe. In                                             mussen said knowing that
covery that could provide       study authors. The research  strain from the one that     contrast to later strains, in-                                         plague existed thousands
clues to how dangerous          was published online Thurs-  caused the three known       cluding the one estimated                                              of years earlier than had
diseases evolve.                day in the journal, Cell.    pandemics, including the     to have wiped out about                                                been believed might ex-
To find evidence of the pre-                                                                                                                                     plain some unsolved histori-
historic infection, research-                                                                                                                                    cal mysteries, including the
ers drilled into the teeth of                                                                                                                                    “Plague of Athens,” a hor-
101 individuals who lived                                                                                                                                        rifying unknown epidemic
in Central Asia and Eu-                                                                                                                                          that struck the Greek capi-
rope some 2,800 to 5,000                                                                                                                                         tal in 430 B.C. It killed up to
years ago. The drilling pro-                                                                                                                                     100,000 people during the
duced a powder that the                                                                                                                                          Peloponnesian War.
researchers examined for                                                                                                                                         “People have been specu-
DNA from plague bacte-                                                                                                                                           lating about what this was,
ria. They found it in samples                                                                                                                                    like was this measles or ty-
from seven people.                                                                                                                                               phus, but it could well have
Before the study, the earli-                                                                                                                                     been plague,” Rasmussen
est evidence of the plague                                                                                                                                       said.
was from A.D. 540, said                                                                                                                                          He said tracking how the
Simon Rasmussen of the                                                                                                                                           plague evolved from be-
Technical University of Den-                                                                                                                                     ing an intestinal infection
mark. He and colleagues                                                                                                                                          to “one of the most deadly
found it as early as 2,800                                                                                                                                       diseases ever encountered
B.C.                                                                                                                                                             by humans” could help sci-
“We were very surprised to                                                                                                                                       entists predict the disease’s
find it 3,000 years before                                                                                                                                       future path.q

Princeton honors memory of ‘Mind’ mathematician John Nash 

PRINCETON, N.J. (AP) —          The Ivy League university’s  Nasar said at the lecture.   Princeton University, receiv-                                          at Princeton since 1995 and
Princeton University said       goodbye included a public    Nasar fondly recalled        ing his doctorate in math-                                             was renowned for his work
farewell to late mathema-       lecture from author Sylvia   Nash’s wife, Alicia Nash,    ematics there in 1950 after                                            in game theory.
tician and faculty member       Nasar, whose biography       saying she was the “hero”    he got his graduate and                                                Crowe played him in “A
John Nash, whose life and       formed the basis for the     of his story.                bachelor’s degrees from                                                Beautiful Mind,” which won
battle with schizophrenia       2001 movie, and a chapel     The Nashes, who were in      the Carnegie Institute of                                              the Academy Award for
were chronicled in the Rus-     service that opened with     their 80s, were killed in a  Technology (now Carnegie                                               best picture. Crowe was
sell Crowe movie “A Beauti-     Bach’s fugue in G minor, a   taxi crash on the New Jer-   Mellon University) in 1948.                                            nominated for an Oscar
ful Mind,” with a day of re-    favorite of Nash’s.          sey Turnpike in May.         Nash, the 1994 Nobel Prize                                             for best actor, and Jenni-
membrance events and a          “We may not see the likes    John Nash, who was known     winner in economics, had                                               fer Connelly, who played
panel discussion about him      of John Nash again, but his  as brilliant and eccentric,  held the position of senior                                            his wife, won the Oscar for
on Saturday.                    story is one for the ages,”  had a long connection with   research mathematician                                                 best supporting actress.q
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