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PCNA-like pattern (AC-13)

HEp-2 cells. Half of the cell nuclei of all interphase cells

exhibit a bright, fi ne speckled basic fluorescence with the

nucleoli being unaffected.The same fl uorescence pattern is

found with the other half, but the intensity is lower by a factor

of 10. The area of the condensed chromosomes is not stained

in the mitosis; the surrounding area of the chromosomes

shows only a weak,fine speckled fl uorescence, corresponding

to the darker nuclei of the interphase cells in pattern and

intensity.

Primate liver is largely negative.