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Infertility, Male   541


             household at a later date (consider artificial   •  Serum progesterone concentrations at that   Technician Tips
             insemination).                     time and weekly if there is any indication   •  Be prepared for many questions from clients
  VetBooks.ir  continue training in the venue in which they   embryonic loss        clients think that all bitches should be bred   Diseases and   Disorders
                                                                                    whose dogs fail to produce puppies. Many
                                                of variability in embryonic vesicle size or
           •  Performance  bitches  may  be  allowed  to
                                                                                    on a particular pair of days from the onset
             compete but under optimal environmental
             and hygiene conditions to minimize risk to
             bitch and fetuses.                 PROGNOSIS & OUTCOME                 of proestrus (e.g., 10th and 12th days) or
                                                                                    every day while she is receptive, and these
                                               •  Good to excellent for clients who comply   preconceived notions should be anticipated
           Drug Interactions                    with breeding management recommendations  and addressed with medical facts.
           Use  care in  the selection  of any  medication   •  Guarded for bitches with uterine disease and/  •  Ensure that serum samples for progesterone
           used in a breeding bitch. For example, topical   or ovarian dysfunction  are collected in appropriate sample tubes.
           corticosteroids that are commonly found in otic   •  Poor for bitches with primary anestrus due
           preparations can be absorbed systemically and   to chromosomal abnormalities  Client Education
           are not recommended.                                                   •  Suggest a reproductive workup before the
                                                PEARLS & CONSIDERATIONS             next anticipated estrous cycle.
           Possible Complications                                                 •  Educate about the value of vaginal cytologic
           •  Mibolerone  causes  clitoral  hypertrophy,   Comments                 evaluation,  vaginal  culture,  and  serum
             epiphora, and tear staining and may   •  Infertility of the stud dog is the second most   progesterone testing
             increase  aggression  toward  other  dogs.   common cause of female infertility after   •  Importance  of  good  semen  and  proper
             This drug can exacerbate  existing liver   improper breeding management. The stud   insemination technique
             enzyme elevation. Dogs with normal liver   dog must also be evaluated and demonstrated
             enzymes rarely have changes as a result of    to produce adequate numbers of motile and   SUGGESTED READING
             the drug.                          morphologically  normal  sperm,  and  the   Wilborn RR, et al: Clinical approaches to infertility
           •  The progestational compounds may cause   semen must be inseminated properly.  in the bitch. Vet Clin North Am Small Anim Pract
             masculinization of female fetuses, mammary   •  Failure to cycle is often a failure to observe   42(3):457-468, 2012
             enlargement, and/or prolong gestation result-  the bitch adequately for physical changes   AUTHOR: Frances O. Smith, DVM, PhD, DACT
             ing in fetal death.                consistent with proestrus. The client should   EDITOR: Michelle A. Kutzler, DVM, PhD, DACT
                                                blot the vulva daily to detect vaginal dis-
           Recommended Monitoring               charge and change in vulvar size and shape
           •  Confirm pregnancy ultrasonographically 30   ± monthly progesterone assays to detect
             days after breeding.               ovulation with unobserved estrus.





            Infertility, Male



            BASIC INFORMATION                  CONTAGION AND ZOONOSIS             PHYSICAL EXAM FINDINGS
                                               Brucella canis                     •  Libido may be normal or decreased.
           Definition                                                             •  Testes may be small and soft or normal in
           •  Spermiogram abnormalities may be catego-  GEOGRAPHY AND SEASONALITY   size and consistency.
             rized as follows:                 Lower total  number  of spermatozoa and   •  Testes, epididymides, or spermatic cords may
             ○   Asthenozoospermia:  decreased  numbers   percentage of morphologically normal sperma-  be enlarged (inflammation or neoplasia) and/
               of progressively motile spermatozoa per   tozoa in summer months expected in North     or thickened.
               ejaculate (<30%-50%)            American dogs                      •  Scrotum  may  be  enlarged  or  thickened
             ○   Teratozoospermia: increased numbers of                             (dermatitis, trauma, edema or fluid
               morphologically abnormal spermatozoa   ASSOCIATED DISORDERS          accumulation).
               per ejaculate (>40%-50%)        ± Poor libido                      •  Prostatomegaly  possible  (symmetrical  or
             ○   Oligozoospermia: abnormally low numbers                            asymmetrical; painful or nonpainful)
               of spermatozoa per ejaculate (<22 million   Clinical Presentation  •  In  dogs  with  asthenozoospermia  due  to
               spermatozoa/kg body weight in the dog   DISEASE FORMS/SUBTYPES       primary ciliary dyskinesia/immotile cilia
               or < 5 million total spermatozoa in the   •  Reversible versus irreversible  syndrome, additional signs may include
               tom)                            •  Compensatory versus noncompensatory  recurrent  nasal  discharge  and/or  cough,
           •  Other causes of male infertility are listed on                        hydrocephalus (open fontanelle, domed
             p. 1247.                          HISTORY, CHIEF COMPLAINT             calvaria), or situs inversus (spleen is palpated
                                               •  Declining or consistently poor fertility  on the right side of the abdomen; heartbeat
           Epidemiology                        •  Recent episode of malaise or fever  is strongest on right hemithorax).
           SPECIES, AGE, SEX                   •  Prior  history  of  heavy  physical  training   •  ± Fever (infectious causes of infertility)
           Dog or cat, intact males, any age    (possibility of performance-enhancing drugs)
                                               •  History  of  bloody  penile  or  preputial   Etiology and Pathophysiology
           RISK FACTORS                         discharge or pain with ejaculation  Causes (all categories):
           Age, systemic disease (especially those resulting   •  History  of  chronic  respiratory  disease   •  Infectious or inflammatory (orchitis, epididy-
           in increased body temperature), endocrinopathy,   (asthenozoospermia)    mitis, prostatitis including infection with B.
           testicular disease or trauma, chemotherapy,                              canis, mycoplasmas or other aerobic bacteria,
           hormone therapy                                                          or feline infectious peritonitis [FIP])

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