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Lymphoma Chemotherapy Treatment Tables, Dog 604.e1

Rabacfosadine/Doxoroubicin Protocol (Dog)
VetBooks.ir Treatment and Monitoring* Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Weeks 7-12 and 13-18 Diseases and Disorders
Repeat as for weeks 1-6
•
•
CBC
•
•
Rabacfosadine
•
Doxorubicin •
*This protocol can be considered as initial therapy for clients not able to pursue frequent visits as with CHOP:
Rabacfosadine 1 mg/kg given as 30 min IV infusion
Doxorubicin for dogs > 15 kg, 30 mg/m ; for dogs <15 kg, 1 mg/kg IV
2
Data from Thamm DM, et al: Alternating rabacfosadine/doxorubicin: Efficacy and tolerability in naïve canine multicentric lymphoma. J Vet Intern Med 31(3): 872-878, 2017.

LOPP Protocol (Dog)
Treatment and Monitoring* Week 1 Week 2 Week 3 Week 4 Weeks 8-12 and thereafter
CBC • • • Repeat as for weeks 1-4
ALT •
CCNU (lomustine) •
Vincristine • •
Procarbazine •
Prednisone •
*This protocol can be considered as initial therapy for T-cell lymphoma and as a follow-up course of treatment for previously treated lymphoma that has relapsed:
2
CCNU (lomustine) 50-60 mg/m PO; recommend concurrent daily Denamarin as long as patient is receiving LOPP.
2
Vincristine 0.5 mg/m IV
2
Procarbazine 50 mg/m PO q 24h for 14 days
2
Prednisone 30 mg/m PO q 24h for 14 days
Adapted from Fahey CE, et al: Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases
(2003-2009). J Am Vet Med Assoc 239(2): 209-215, 2011.

MOPP Protocol (Dog)
WEEKS WEEKS 5
WEEK 1 WEEK 2 3 AND 4 AND 6
Treatment and Day Day Day Day Day Day Day Day Day Day Day Day Day Day Days Days
Monitoring* 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14-27 28-41
CBC † • • Repeat
Mechlorethamine • • all as
for days
Predniso(lo)ne • • • • • • • • • • • • • • 1-13
Procarbazine • • • • • • • • • • • • • •
Vincristine • •

*This protocol is considered for rescue therapy of resistant lymphoma and has been used only as a follow-up course of treatment for previously treated lymphoma that has relapsed.
† Complete blood count (CBC) to screen for cytopenias, which could delay, reduce, or cancel the week’s treatment(s):
2
Mechlorethamine 3 mg/m IV
Predniso(lo)ne 30-40 mg/m PO q 24h
2
2
2
Procarbazine 50 mg/m PO q 24-48h; because procarbazine is available as 50-mg capsules, dogs > 0.8 m body surface area (BSA) receive dose rounded to closest 50-mg; dogs > 0.4 m but < 0.8 m 2
2
2
BSA receive dose rounded to closest 50-mg but q 48h instead of q 24h; and dogs < 0.4 m BSA receive reformulated drug in 10-mg capsules administered to nearest 20-mg increment.
2
Vincristine 0.7 mg/m IV
Data from Rassnick KM, et al: MOPP chemotherapy for treatment of resistant lymphoma in dogs: a retrospective study of 117 cases (1989-2000). J Vet Intern Med 16(5):575-580, 2002; Rassnick KM,
et al: Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs. Vet Comp Oncol 8(4):243-253, 2010; Rassnick
KM, et al: Comparison of 3 protocols for treatment after induction of remission in dogs with lymphoma. J Vet Intern Med 21(6):1364-1373, 2007; Brodsky EM, et al: Asparaginase and MOPP treatment of
dogs with lymphoma. J Vet Intern Med 23(3):578-584, 2009.
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