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604.e2 Lymphoma Chemotherapy Treatment Tables, Dog

DMAC Protocol (Dog)
VetBooks.ir Treatment and Week Week Week Week Week Week Week Week Week Week Week Week
10
11
‡
Monitoring*
9
8
1
4
6
5
3
7
12
†
2
•
•
•
•
•
§
•
•
•
•
•
•
•
CBC
Dexamethasone • • • • • • • • • • • •
Actinomycin D • • • • • •
Cytosine arabinoside • • • • • •
Melphalan • • • •
Chlorambucil • •
*This protocol is considered for rescue therapy of resistant lymphoma and has been used only as a follow-up course of treatment with previously treated lymphoma that has relapsed.
† Day of first treatment.
‡ After weeks 10-16, if complete remission has been achieved, consider maintenance therapy with LMP (chlorambucil, methotrexate, prednisone) or CCNU/prednisone.
§ Complete blood count (CBC) to screen for cytopenias, which could delay, reduce, or cancel the week’s treatment(s):
Dexamethasone 1 mg/kg PO or SQ
2
Actinomycin D 0.75 mg/m IV
2
Cytosine arabinoside 300 mg/m SQ once or as a 4-hour constant-rate infusion IV
Melphalan 20 mg/m PO
2
Chlorambucil 20 mg/m PO
2
Adapted from Alvarez FJ, et al: Dexamethasone, melphalan, actinomycin D, cytosine arabinoside (DMAC) protocol for dogs with relapsed lymphoma. J Vet Intern Med 20:1178-1183, 2006.
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Lymphoma, Peripheral or Multicentric

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