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Shar-pei Fever 908.e3

may be tried to decrease degradation of ○ Does not eliminate amyloid already • Colchicine treatment may help prevent or
hyaluronan. deposited and does not reverse organ delay amyloidosis
VetBooks.ir and subsequent organ failure with the use ○ Dogs on colchicine should receive cobala- Technician Tips Diseases and Disorders
• Attempt to prevent amyloid deposition
damage
Shar-pei fever should be considered in any
of colchicine.
min supplementation.
• Management of chronic kidney or liver
• Supportive care for chronic kidney disease
disease associated with late-stage disease is • Use of DMSO is optional. Shar-pei with an elevated temperature, especially
if the patient has swollen hocks.
difficult and largely supportive. (pp. 167 and 691)
• Liver disease: dogs can respond to supportive Client Education
Acute General Treatment care and colchicine therapy • Closely monitor temperature of an animal
• If fever > 105°F (40.6°C), the patient may during a fever episode.
need hospitalization, intensive antipyretic Drug Interactions • Monitor the patient’s lab work if treating
management (p. 421), and NSAIDs for Colchicine is metabolized by cytochrome P450s with colchicine.
fever (e.g., carprofen 2.2 mg/kg SQ q 12h). and is a substrate for MDR1 protein. It may • Inform the owner of the guarded long-term
• Presentation in early stage, temperature interact negatively with many drugs. A dog on prognosis.
≤ 105°F (40.6°C): NSAIDs for fever (e.g., colchicine and ketoconazole developed severe
carprofen 2.2 mg/kg PO q 12h; meloxicam hepatotoxicity and myopathy that resolved after SUGGESTED READING
0.1 mg/kg PO q 24h) discontinuation of both drugs. Olsson M, et al: Thorough investigation of a canine
• Presentation in late stage: immediate sup- autoinflammatory disease (AID) confirms one
portive care Possible Complications main risk locus and suggests a modifier locus for
○ Judicious use of IV fluids for volume • Colchicine has a narrow therapeutic index amyloidosis. Plos One 8;e75242, 2013.
resuscitation/rehydration and diuresis and can cause anorexia, vomiting, diarrhea,
if renal failure (pp. 23 and 169). For pancytopenia, and myopathy in people. ADDITIONAL SUGGESTED
nephrotic syndrome (p. 691), fluids may • Vomiting and diarrhea have been reported READINGS
worsen edema and be contraindicated. in dogs taking colchicine and may resolve Loeven KO: Hepatic amyloidosis in two Chinese
○ Antacids for vomiting, anorexia, or other with dose reduction. Shar-pei dogs. J Am Vet Med Assoc 204;1212-
evidence consistent with uremic gastropa- 1216, 1994.
thy (e.g., omeprazole 0.7-1.5 mg/kg PO Recommended Monitoring McAlister A, et al: Adverse interaction between
q 12-24h; famotidine 0.5-1 mg/kg PO Periodic CBC (especially if on colchicine), colchicine and ketoconazole in a Chinese Shar
or IV q 12-24h) serum biochemistry profile, and urinalysis with pei. J Am Anim Hosp Assoc 50;417-423, 2014.
○ Antihypertensives for systemic hyperten- urine protein/creatinine ratio Metzger J, et al: A study of Shar-pei dogs refutes
sion (e.g., enalapril 0.7 mg/kg PO q 24h association of the ‘meatmouth’ duplication near
HAS2 with familial Shar-pei fever. Anim Genet
and/or amlodipine 0.125-0.5 mg/kg PO PROGNOSIS & OUTCOME 45;762-764, 2014.
q 12-24h) Segev G, et al: Renal amyloidosis in dogs: a retrospec-
○ Drug dosages and/or intervals may need • Early stage: guarded to fair long-term tive study of 91 cases with comparison of the disease
to be adjusted if moderate to severe renal prognosis; colchicine may improve survival between Shar-pei and non–Shar-pei dogs. J Vet
disease is present. • Late stage: very poor; most dogs die of Intern Med 26;259-268, 2013.
uremia/renal failure, and thromboembolism Tintle LJ: Familial Shar-pei fever and familial
Chronic Treatment and hepatic rupture have also been reported amyloidosis of Chinese Shar-pei dogs. http://wvc.
vetstreet.com/familial-Shar-pei-fever/.
• Colchicine decreases inflammation by Winston JA, et al. Familial Shar-pei fever. Clinician’s
reducing motility of neutrophils. A dose of PEARLS & CONSIDERATIONS Brief September:61-65. 2013.
0.01-0.03 mg/kg PO q 12-24h is suggested
for dogs, depending on gastrointestinal (GI) Comments RELATED CLIENT EDUCATION
tolerance. People receive no more than 3 mg • Shar-pei dogs with episodic fever are at high
daily. risk for amyloidosis. SHEETS
○ Used in people with familial Mediter- • The most common cause of renal failure in
ranean fever to minimize frequency and Shar-pei dogs is renal amyloidosis. Chronic Kidney Disease
severity of fever attacks and to prevent • The presentation of renal failure may occur Consent to Perform Abdominal Ultrasound
kidney failure; no controlled trials or proof suddenly, mimicking acute kidney injury. Consent to Perform Arthrocentesis
of efficacy in Shar-pei dogs How to Collect a Urine Sample
○ Recommended early in the course of the Prevention Hypertension, Systemic
disease in an attempt to prevent or delay • Genetic testing before breeding (Shar-Pei AUTHOR: Orla Mahony, MVB, DACVIM, DECVIM,
development of amyloidosis; no effect on Auto-inflammatory Disease genetic test from MRCVS
fibrosis once established Cornell AHDC) EDITOR: Jonathan E. Fogle, DVM, PhD, DACVIM
○ Often initiated after first or second bout of • Removal of affected dogs from the breeding
otherwise unexplained fever or lameness. pool

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