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Urethral Obstruction (Feline): Medical Management   1177


           •  Inform owners of the possibility of urinary   Excessive  manipulation  or  compression   •  When indicated, 3- or 5-Fr, flexible feeding
             bladder rupture and guarded short-term   of a devitalized, overdistended bladder wall   tubes composed of material that minimizes
  VetBooks.ir  Possible Complications and         painful, inadequately anesthetized patient   •  To minimize urethral trauma, avoid open-end
                                                                                    foreign  body  inflammatory  response  are
             prognosis with or without therapy.
                                                  or excessive abdominal compression by a
                                                                                    preferred.
                                                  may promote rupture.
           Common Errors to Avoid
                                                                                    catheters with sharp stylets.
           •  Cats with urethral obstruction and cardiovas-  ○   Advantages of decompressive cystocentesis  •  Indications
                                                     Obtaining urine sample for analysis and
                                                  ■
             cular collapse rarely show overt signs referable   culture             ○   Inadequate/poor  urine  stream  after
             to the urinary system at the time of presenta-  ■   Temporarily halting the adverse meta-  urethral flushing
             tion. Assessment of urinary bladder size (i.e.,   bolic effects of obstruction  ■   Urethral spasm/swelling (≈1-3 days)
             palpation  or  medical  imaging)  is  essential   ■   Reducing intraluminal bladder pressure   ■   Excessive  urinary  precipitates  (≈1-2
             to  avoid  overlooking  urethral  obstruction   to facilitate retropulsion  days)
             as the primary cause for cardiovascular or   ■   Reducing pain associated with bladder   ○   Assist  correction  of  postrenal  azotemia
             respiratory distress.                  overdistention                    (≈1-2 days).
           •  Survey  radiography  is  essential  to  verify,   ○   Disadvantages   of   decompressive   ○   Promote recovery of detrusor contractility
             localize, and search for the underlying cause   cystocentesis            (≈1-5 days).                    Procedures and   Techniques
             of obstruction; radiographs should be per-  ■   Potential  extravasation  of  urine  into   ○   Promote repair of urothelial urethral tear
             formed early in the diagnostic process before   peritoneal cavity        (≈3-10 days).
             initiation of therapy. Non-obstructed dysuric   ■   Bladder wall trauma  •  Care and management
             cats usually have small urinary bladders.  •  Flushing  plug  contents  out  the  external   ○   Place  as  atraumatically  and  cleanly  as
           •  Unsuccessful bladder expression is an unreli-  urethral orifice         possible.
             able  and  sometimes  unsafe  (i.e.,  bladder   ○   Attach open-ended catheter, IV extension   ○   Maintain a closed collection system.
             rupture)  method  of  confirming  urethral   tubing,  and  large  (35-mL)  fluid-filled   ○   Remove indwelling catheters as soon as
             obstruction.                         syringe in that order. Displace air in the   possible.
           •  Unsuccessful  transurethral  insertion  of   tubing by filling tubing and catheter with   ○   If urine is initially sterile, avoid antimi-
             urinary catheters is an unreliable and some-  fluid from the syringe before insertion in   crobial therapy until catheter is removed.
             times unsafe (i.e., urethral tear, rupture, and   the urethra.         ○   If  urine  is  initially  infected,  treat  the
             subsequent stricture) method of confirming   ○   Insert tip of catheter into distal urethral   infection (p. 232).
             and localizing urethral obstruction.  opening.                         ○   Treat potentially life-threatening infections.
           •  Caustic,  strongly  acidic  flushing  solutions   ○   Flush a large quantity of sterile isotonic   ○   Do not give the cat corticosteroids.
             are contraindicated.                 solution into the urethral lumen, allowing   •  Nutritional  therapy  to  dissolve  struvite
                                                  it to reflux out the external urethral orifice.   crystals,  urethral  plugs,  or  small  struvite
           Procedure                              The goal is to break up a urethral plug,   uroliths (p. 1016)
           •  Sedate or anesthetize the patient. Consider   similar to massaging the urethra.  •  Analgesia (1-2 days). Nonsteroidal antiinflam-
             epidural anesthesia to locally control pain   ○   Subsequent  application  of  steady  but   matory drugs (NSAIDs) are contraindicated
             and thereby minimize the quantity and risk   gentle digital pressure to the bladder wall   in cats with compromised renal function or
             of general anesthetics.              may result in expulsion of a urethral plug.  dehydration.
           •  To fragment urethral plugs, gently massage   ○   This method is unlikely to flush uroliths   •  Prevent negative fluid balance associated with
             the distal urethra and cautiously compress the   back into the urinary bladder.  postobstructive diuresis by giving parenteral
             urinary bladder with the goal of promoting   •  Retrograde  urethral  flushing  (to  propel   fluids.
             expulsion of plugs. This is easy to perform   intraluminal contents into urinary bladder)  •  The following drugs are commonly adminis-
             but not commonly effective.        ○   Attach open-ended catheter, IV extension   tered to cats without proven efficacy, safety,
           •  Decompressive cystocentesis         tubing, and fluid-filled syringe (3-12 mL)   or physiologic justification: urethral smooth-
             ○   Attach  a  1 2 -inch,  22-gauge  needle,   in that order. Displace air in the tubing   muscle relaxants (e.g., phenoxybenzamine,
                        1
               IV extension tubing, and a 3-way stop-  by filling tubing and catheter with fluid   prazosin),  urethral  antispasmodics  (e.g.,
               cock.  Then  use  a  large-volume  syringe   from the syringe before insertion in the    propantheline, oxybutynin), parasympatho-
               (20-35 mL) to remove urine from bladder,   urethra.                  mimetics  (e.g.,  bethanechol),  and  skeletal
               inserting the needle at the center of the   ○   Insert tip of catheter into distal urethral   muscle relaxants (e.g., diazepam, dantrolene).
               bladder with the needle directed obliquely   opening.                If used at all, should be closely monitored.
               (caudodorsally).                 ○   With a moistened gauze sponge, occlude
             ○   By  using  the  IV  extension  tubing  and   the distal urethra around the catheter.
               3-way stopcock between the needle and   ○   Pull the penile urethra caudally to extend
               syringe, the urinary bladder will not have   it parallel to the vertebral column.
               to be repunctured to empty a syringe full   ○   Flush fluid vigorously by emptying syringe.
               of urine.                        ○   Repeat urethral flushing if needed while
             ○   Excessive digital pressure should not be   also remembering to repeat decompressive
               applied  to  the  bladder  wall  while  the   cystocentesis if bladder lumen becomes
               needle is in the lumen to prevent urine   distended with flushing solution.
               from being forced around the needle into   ○   The greatest pressure to retrograde hydro-
               the peritoneal cavity.             propulse  is  achieved  with  the  smallest
             ○   Attempting complete evacuation of the   syringe.
               bladder lumen is undesirable because     •  In some cases, radiographs are indicated to
               the sharp point of the needle may damage   verify return of uroliths into urinary bladder
               the bladder wall. The authors recommend   or assess catheter placement.
               that  5-15 mL  of  urine  remain  in  the                          URETHRAL OBSTRUCTION (FELINE): MEDICAL
               bladder.                        Postprocedure                      MANAGEMENT  Assembled catheter, IV extension
             ○   Properly performed cystocentesis should   Indwelling transurethral catheters:  tubing, and syringe to facilitate removing obstruction
               not  contribute  to  bladder  rupture.   •  Not always indicated   in the urethra of cats.

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