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Hypoparathyroidism: Management 1429.e1



            Hypoparathyroidism: Management
  VetBooks.ir

                                          Confirmed hypocalcemia
                                          and hyperphosphatemia




               Decreased serum albumin and/or increased  Normal serum albumin concentration and
             blood urea nitrogen (BUN) and serum creatinine  normal BUN and serum creatinine levels




               •  Investigate other causes of hypocalcemia
               •  Measure serum ionized calcium level
                                                       High-normal or     Decreased or low-normal
                                                      increased PTH?         serum parathyroid
                                                                           hormone (PTH) level?
                                           Yes
                                                                                    Yes
                                   Patient is showing no signs or mild clinical signs
                                      (e.g., intermittent muscle fasciculations)  Initiate treatment for
                                                                            hypoparathyroidism

                                                                                      Patient is showing severe clinical
                                                                                      signs referable to hypocalcemia
                                                                                      (e.g., tetany, hyperthermia)
              • Calcitriol 0.01–0.02 mcg/kg orally q
               24h; adjust long-term based
               on response
              • Calcium carbonate: 25 mg/kg elemental                          • Connect electrocardiographic (ECG) monitor
               calcium (= 62.5 mg/kg calcium carbonate)  Once stabilized         and administer calcium gluconate 10%
               orally q 24h                                                      injectable solution: 0.5-1.5 mL/kg IV slowly
              • Dihydrotachysterol no longer available in                        (10-15 minutes) to effect,
               USA (dose 0.01-0.02 mg/kg orally q 24h                            while monitoring for efficacy (visible
               if available) in place of calcitriol                              reduction in clinical signs) and/or signs
                                                                                 of excess
                                                                                 (e.g., bradycardia or QT interval shortening
                                                                                 on ECG)
                                                                               • Measure serum magnesium and
                     Recheck serum calcium twice                                 supplement as necessary
                   weekly until in mid-normal range.

           UPDATED AND EDITED BY: Leah A. Cohn, DVM, PhD, DACVIM
           ORIGINALLY WRITTEN BY: Cary L. M. Bassett, DVM, DACVIM




                                                                                                                      Clinical   Algorithms





















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