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132   Bronchiectasis


            PROGNOSIS & OUTCOME                Decontamination Recommendations for Bromethalin Ingestion

  VetBooks.ir  •  Good prognosis for patients with a recent   Dose Ingested (mg/kg)  Time Since Exposure  Treatment
            exposure that are promptly and properly
                                               Dogs
            decontaminated
                                               0.1-0.49
                                                                                                 Emesis or 1 dose AC
                                                                                <4
           •  Fair prognosis for patients that ingested a
            dose below the LD50 and have mild signs.                            >4               1 dose AC
            Signs may resolve over the course of days   0.5-0.75                <4               Emesis + AC q 8h for 24h
            to weeks, or they may progress.                                                      (3 doses total)
           •  Grave prognosis for patients with severe signs                    >4               AC q 8h for 24h
            of seizures, tremors, or coma                                                        (3 doses total)
                                               >0.75                            <4               Emesis + AC q 8h for 48h
            PEARLS & CONSIDERATIONS                                                              (6 doses total)
           Comments                                                             >4               AC q 8h for 48h
           •  Identification of the ingredient and concen-                                       (6 doses total)
            tration should be taken directly from the   Cats
            packaging  whenever  possible.  The  U.S.   0.05-0.1                <4               Emesis or 1 dose AC
            Environmental  Protection Agency (EPA)                              >4               1 dose AC
            registration number can be used to accurately
            identify the bait. Clinicians should be wary   0.1-0.3              <4               Emesis + AC q 8h for 24h
            of identifications made from Internet searches                                       (3 doses total)
            as packages that look similar in appearance                         >4               AC q 8h for 24h
            may contain bait with different active                                               (3 doses total)
            ingredients.                       >0.3                             <4               Emesis + AC q 8h for 48h
           •  Rodenticides that contain 0.01% bromethalin                                        (6 doses total)
            contain  0.1 mg/g  bromethalin.  There  are                         >4               AC q 8h for 48h
            2.84 mg of bromethalin in each ounce of                                              (6 doses total)
            0.01% bait. The LD50 for dogs is 2.4 to
            5.6 mg/kg.                        AC, Activated charcoal.
           •  Patients  that  develop  CNS  signs  while   Data from ASPCA: APCC’s decontamination recommendations for bromethalin ingestion.  https://www.aspcapro.org/sites/default/
            receiving activated charcoal should have   files/0903toxbrief_0.pdf.
            hypernatremia ruled out before starting other
            treatments.
                                              scenario amount ingested, and when the   •  Keep all packaging from rodenticides so it
           Prevention                         exposure occurred. Encourage clients to retrieve   can be referenced if needed.
           Place rodenticides in areas inaccessible to     bait packaging and investigate for remaining
           pets.                              bait when necessary.               SUGGESTED READING
                                                                                 Tourdot R: The decontamination dilemma: brometh-
           Technician Tips                    Client Education                     alin ingestion. Todays Vet Pract Jan/Feb:95-100,
           An accurate history is vital for successful treat-  •  Place  rodenticides  in  areas  inaccessible  to   2017.
           ment of bromethalin ingestions. Determine the   pets; pet-resistant bait stations are not   AUTHOR: Renee Tourdot, DVM
           exact identification of the bait, the worst-case   completely pet-proof.  EDITOR: Tina Wismer, DVM, MS, DABVT, DABT




            Bronchiectasis                                                           Bonus Material   Client Education
                                                                                                         Sheet
                                                                                          Online

            BASIC INFORMATION                 •  In  dogs,  either  sex  equally  affected;  male   ○   Bronchopneumonia (p. 795)
                                                cats may be overrepresented        ○   Immunosuppressive states
           Definition                                                              ○   Neoplasia
           Irreversible, pathologic dilation of airways due   GENETICS, BREED PREDISPOSITION
           to destruction of elastic and muscular compo-  American cocker spaniel, West Highland white   ASSOCIATED DISORDERS
           nents of airway walls              terrier, miniature and standard poodles, Siberian   Bronchopneumonia
                                              husky, Alaskan malamute, English springer
           Epidemiology                       spaniel, and beagle may have an increased     Clinical Presentation
           SPECIES, AGE, SEX                  risk.                              DISEASE FORMS/SUBTYPES
           •  Dogs > cats; cats frequently subclinical                           •  Focal, multifocal, and diffuse distribution
           •  Young if associated with congenital abnor-  RISK FACTORS           •  Cylindrical, saccular, and cystic forms
            malities (rare)                   •  Congenital  defects  (e.g.,  primary  ciliary
           •  Older  (i.e.,  dogs  > 10 years have an   dyskinesia, immunodeficiency diseases)  HISTORY, CHIEF COMPLAINT
            increased risk) if associated with chronic    •  Acquired diseases   •  Incidental radiographic finding in the absence
            inflammation (e.g., chronic bronchitis, eosin-  ○   Chronic bronchitis (p. 136)  of clinical signs (especially in cats), or
            ophilic bronchopneumopathy), infection, or     ○   Eosinophilic   bronchitis/eosinophilic   •  Cough
            neoplasia                             bronchopneumopathy (p. 298)    •  Tachypnea

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