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Gastrinoma 382.e3

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○ H K -ATPase (proton pump) inhibitors Recommended Monitoring SUGGESTED READING
(omeprazole 0.7-1.5 mg/kg PO q 12-24h); According to clinical signs Gal A, et al: An unusual clinical presentation of a
VetBooks.ir ○ Somatostatin analog (octreotide 10- PROGNOSIS & OUTCOME ADDITIONAL SUGGESTED Diseases and Disorders
considered superior to H2-receptor antago-
dog with gastrinoma. Can Vet J 52:641, 2011.
nists for suppression of acid secretion
40 mcg/DOG q 8-12h)
• Animals that are managed medically and
• Promote healing. • Poor due to high rate of metastasis READINGS
○ Sucralfate 0.25-1 g/DOG PO q 6-12h surgically live 1 week to 18 months (mean, Hughes SM: Canine gastrinoma: a case study and
literature review of therapeutic options. N Z Vet
○ Misoprostol 1-7.5 mcg/kg PO q 8h 4.8 months). J 54:242, 2006.
• Surgical and medical management for GI Parente NL, et al: Serum concentrations of gastrin
ulceration/perforation PEARLS & CONSIDERATIONS after famotidine and omeprazole administration to
dogs. J Vet Intern Med 28:1465, 2014.
Chronic Treatment Comments Simpson K, et al: Diagnosis and treatment of
• Acute treatment management, along with A palpable abdominal mass or one that is visual- gastrinoma. Semin Vet Med Surg (Small Anim)
antiemetics ized on ultrasound or at surgery is uncommon 12:274, 1997.
• Surgical debulking of the primary and with gastrinoma.
metastatic lesions decreases clinical signs RELATED CLIENT EDUCATION
associated with gastrinomas. Technician Tips SHEETS
• Chemotherapy, receptor-mediated radio- Ensure that antacid medication has been
therapy, and long-acting somatostatin discontinued for 7 days before obtaining a Consent to Perform Abdominal Ultrasound
analogs (+/− alpha-interferon) yield mixed fasting serum gastrin level. Consent to Perform Endoscopy, Upper GI
responses. (Gastroduodenoscopy)
Client Education
Possible Complications • Monitor for recurrence of clinical signs. AUTHOR: M. Raquel Brown, DVM, DACVIM
Anemia; GI ulceration/perforation if hyper- • Rapid deterioration is possible if GI perfora- EDITOR: Rance K. Sellon, DVM, PhD, DACVIM
acidity is not controlled; common bile duct tion occurs.
obstruction if due to a duodenal gastrinoma

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